Evidence map›Paper›PMID 40868117›Full record

ReviewBiomedicines2025

The Clinical Spectrum of Acquired Hypomagnesemia: From Etiology to Therapeutic Approaches.

Matteo Floris, Andrea Angioi, Nicola Lepori, Doloretta Piras, Gianfranca Cabiddu, Antonello Pani, Mitchell H Rosner

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matteo FlorisNephrology, Dialysis and Transplantation Unit, ARNAS G. Brotzu, 09134 Cagliari, Italy.ORCID 0000-0001-5557-9791
Andrea AngioiNephrology, Dialysis and Transplantation Unit, ARNAS G. Brotzu, 09134 Cagliari, Italy.ORCID 0000-0001-8311-5409
Nicola LeporiNephrology, Dialysis and Transplantation Unit, ARNAS G. Brotzu, 09134 Cagliari, Italy.
Doloretta PirasNephrology, Dialysis and Transplantation Unit, ARNAS G. Brotzu, 09134 Cagliari, Italy.
Gianfranca CabidduNephrology, Dialysis and Transplantation Unit, ARNAS G. Brotzu, 09134 Cagliari, Italy.
Antonello PaniNephrology, Dialysis and Transplantation Unit, ARNAS G. Brotzu, 09134 Cagliari, Italy.
Mitchell H RosnerDivision of Nephrology, University of Virginia Health System, Charlottesville, VA 22903, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypomagnesemia is a frequent and often underrecognized electrolyte disturbance with important clinical consequences, especially in hospitalized and critically ill patients. This multifactorial condition arises from impaired intestinal absorption, renal magnesium wasting, and the effects of various medications. Magnesium, the second most abundant intracellular cation, is crucial in enzymatic and physiological processes; its deficiency is associated with neuromuscular, cardiovascular, and metabolic complications. This narrative review focuses on the mechanisms and clinical consequences of drug-induced hypomagnesemia, highlighting the major drug classes involved such as diuretics, antibiotics, antineoplastic agents, and immunosuppressants. Management strategies include magnesium supplementation and adjunctive therapies like amiloride and SGLT2 inhibitors to reduce renal magnesium losses. Recognizing and addressing drug-induced hypomagnesemia is essential to improve patient outcomes and prevent long-term complications.

Indexed as

adverse effectscancercetuximabdrughypokalemiahypomagnesemiamagnesiummalabsorptionplatinumproton pump inhibitors (PPIs)sodium-glucose cotransporter 2 inhibitors (SGLT2i)therapy

Identifiers

PMID40868117
PMCPMC12383300

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.