Evidence map›Paper›PMID 40868185›Full record

ReviewBiomedicines2025

The Multifaceted Role of Growth Differentiation Factor 15 (GDF15): A Narrative Review from Cancer Cachexia to Target Therapy.

Daria Maria Filippini, Donatella Romaniello, Francesca Carosi, Laura Fabbri, Andrea Carlini, Raffaele Giusti, Massimo Di Maio, Salvatore Alfieri, Mattia Lauriola, Maria Abbondanza Pantaleo and 4 more

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daria Maria FilippiniMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0003-3328-7282
Donatella RomanielloDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, Università di Bologna, 40138 Bologna, Italy.
Francesca CarosiMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0009-0003-2979-6495
Laura FabbriMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Andrea CarliniMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0009-0006-4575-8300
Raffaele GiustiMedical Oncology Unit, Sant'Andrea Hospital of Rome, 00189 Rome, Italy.ORCID 0000-0003-4592-8868
Massimo Di MaioDepartment of Oncology, University of Turin, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, 10126 Turin, Italy.ORCID 0000-0001-8906-3785
Salvatore AlfieriHead and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.ORCID 0000-0001-8485-2275
Mattia LauriolaDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, Università di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-7966-0065
Maria Abbondanza PantaleoMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Lorena ArribasClinical Nutrition Unit, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.ORCID 0000-0002-9683-9999
Marc OlivaDepartment of Medical Oncology, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, 08001 Barcelona, Spain.ORCID 0000-0001-5352-8130
Paolo BossiDepartment of Medical Oncology and Hematology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.
Laura Deborah LocatiDepartment of Internal Medicine and Medical Therapy, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-3315-2580

Funding

PNRR HEAL ITALIA - Health Extended Alliance for Innovative Therapies, Advanced Lab-research, and Integrated Approches of Precision Medicine - PE0000019, to Tommaso Pippucci CUP F33C22000500006.
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cachexiacancer biomarkerchemotherapy resistanceGDF15GFRALhead and neck cancer

Identifiers

PMID40868185
PMCPMC12383714

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.