Evidence map›Paper›PMID 40868270›Full record

ArticleBiomedicines2025

The Transgenerational Impact of High-Fat Diet and Diabetic Pregnancy on Embryonic Transcriptomics and Mitochondrial Health.

Abigail K Klein, Benjamin P Derenge, Malini Mukherjee, Srikrishna P Reddy, Tricia D Larsen, Prathapan Ayyappan, Tyler C T Gandy, Kyle M Siemers, Michael S Kareta, Michelle L Baack

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abigail K KleinSanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.ORCID 0009-0000-5168-3962
Benjamin P DerengeSanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.
Malini MukherjeeSanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.
Srikrishna P ReddySanford School of Medicine, University of South Dakota, 1400 W. 22nd St., Sioux Falls, SD 57015, USA.
Tricia D LarsenSanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.ORCID 0000-0002-9015-3929
Prathapan AyyappanSanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.
Tyler C T GandySanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.
Kyle M SiemersSanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.ORCID 0000-0001-8765-5103
Michael S KaretaSanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.ORCID 0000-0002-6980-9065
Michelle L BaackSanford Research, 2301 E. 60th St. North, Sioux Falls, SD 57104, USA.ORCID 0000-0001-5966-669X

Funding

Dietary interventions to modulate heart health in offspring born to diabetic mothers and the subsequent generation.R01HL160980 · NHLBI · SANFORD RESEARCH/USD · 2022 to 2025
$1.7M
NHLBI NIH HHS R01 HL160980NIGMS NIH HHS P20 GM103548NIGMS NIH HHS P20 GM103620NIH/NHLBI R01HL160980NIH/NIGMS 2P20GM103620
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

diabetesembryohigh fatmitochondriaovernutritionoxidative stresstranscriptometransgenerational

Identifiers

PMID40868270
PMCPMC12383359

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.