Evidence map›Paper›PMID 40868784›Full record

ArticleGels (Basel, Switzerland)2025

Enzyme-Triggered Formation of Tensegrity Structures for Mechanospatial Manipulation of Hydrogels.

Juan Wang, Xu Han, Qingtai Li, Meng Qin, Bin Xue, Wenxu Sun, Yi Cao, Wei Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan WangCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210008, China.
Xu HanCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210008, China.
Qingtai LiCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210008, China.
Meng QinCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210008, China.
Bin XueCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210008, China.ORCID 0000-0002-0822-6501
Wenxu SunCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210008, China.
Yi CaoCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210008, China.ORCID 0000-0003-1493-7868
Wei SunCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210008, China.ORCID 0000-0002-9179-1367

Funding

Anhui Provincial Natural Science Foundation 2308085QE156China Postdoctoral Science Foundation 2024M761390Fundamental Research Funds for the Central Universities 020414380232Fundamental Research Funds for the Central Universities 020514380274Nanjing Municipal Science and Technology Bureau 202205020Nanjing Municipal Science and Technology Bureau 202305001National Key R&D Program of China 2024YFA0919300National Natural Science Foundation of China 52305188National Natural Science Foundation of China T2225016National Natural Science Foundation of China T2322010Natural Science Foundation of Jiangsu Province BK20220600Research Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2025008BResearch Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2025009BResearch Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2025010BResearch Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2025011BShandong Provincial Laboratory Project SYS202202
6 · The paper itself

Abstract

Hydrogels with spatially programmable mechanical properties hold great potential for use in biomedical applications. Inspired by the architecture of the cytoskeleton, we present a strategy for constructing tensegrity-structured hydrogels (TS-Gels) through enzyme-triggered crystal growth to enable precise mechanospatial manipulation. Specifically, alkaline phosphatase (ALP) was covalently anchored to a polyacrylamide (PAAm) hydrogel matrix to catalyze the in situ dephosphorylation of phosphotyrosine precursors, leading to the formation of rigid tyrosine crystals. These crystals functioned as compressive sticks, establishing tensegrity structures within the hydrogel network. By tuning the crystallization kinetics, both the structural morphology and mechanical reinforcement could be precisely controlled. The resulting TS-Gels exhibited significantly enhanced local tensile strength and stiffness, allowing for spatial-mechanical patterning via photo-initiated printing, mold-assisted shaping, and laser engraving. Furthermore, the unique mechanospatial tunability of TS-Gels was demonstrated in tribological surface engineering, underscoring their potential for use in tissue engineering and responsive biomaterials.

Indexed as

biomaterialshydrogelmechanical propertiestyrosine crystals

Identifiers

PMID40868784
PMCPMC12385324

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.