Evidence map›Paper›PMID 40869005›Full record

SynthesisInternational journal of molecular sciences2025

Atomistic-Level Insights into the Role of Mutations in the Engineering of PET Hydrolases: A Systematic Review.

Athina Karaoli, Haralampos Tzoupis, Konstantinos D Papavasileiou, Anastasios G Papadiamantis, Dimitris G Mintis, Chris T Kiranoudis, Iseult Lynch, Georgia Melagraki, Antreas Afantitis

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Athina KaraoliDepartment of ChemInformatics, NovaMechanics Ltd., Nicosia 1070, Cyprus.ORCID 0009-0009-3618-153X
Haralampos TzoupisDepartment of ChemInformatics, NovaMechanics Ltd., Nicosia 1070, Cyprus.ORCID 0000-0002-1534-2762
Konstantinos D PapavasileiouDepartment of ChemInformatics, NovaMechanics Ltd., Nicosia 1070, Cyprus.ORCID 0000-0002-2322-7422
Anastasios G PapadiamantisDepartment of ChemInformatics, NovaMechanics Ltd., Nicosia 1070, Cyprus.ORCID 0000-0002-1297-3104
Dimitris G MintisDepartment of ChemInformatics, NovaMechanics Ltd., Nicosia 1070, Cyprus.
Chris T KiranoudisSchool of Chemical Engineering, National Technical University, Zografou, 15780 Athens, Greece.
Iseult LynchEntelos Institute, Nicosia 2102, Cyprus.ORCID 0000-0003-4250-4584
Georgia MelagrakiDivision of Physical Sciences and Applications, Hellenic Military Academy, 16672 Vari, Greece.
Antreas AfantitisDepartment of ChemInformatics, NovaMechanics Ltd., Nicosia 1070, Cyprus.ORCID 0000-0002-0977-8180

Funding

Horizon Europe 101072777
6 · The paper itself

Abstract

Plastic pollution is a growing global challenge, and traditional plastic waste management methods are proving inadequate in tackling the issue. Enzymatic biodegradation has emerged as a promising alternative or addition to plastic waste management due to its environmentally friendly profile. Polyethylene terephthalate (PET) is among the most widely used polymers in packaging, and recent research has identified several PET-degrading enzymes, such as TfCut2,

Indexed as

HydrolasesMutationPolyethylene TerephthalatesProtein EngineeringBiodegradation, EnvironmentalMolecular Dynamics SimulationHydrolasesPolyethylene Terephthalatesenzymatic degradationmolecular dynamicsPETplasticspoly(ethylene) terephthalatesite-directed mutagenesis

Identifiers

PMID40869005
PMCPMC12387008

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.