Evidence map›Paper›PMID 40869055›Full record

ArticleInternational journal of molecular sciences2025

Modulation of Voltage-Gated Sodium Channels from Sensory Neurons by Isoeugenol.

David Ghim, Jehan Dib, Luiz Moreira-Junior, Joao Carvalho-de-Souza

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David GhimArizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ 85308, USA.
Jehan DibArizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ 85308, USA.
Luiz Moreira-JuniorSuperior Institute of Biomedical Sciences, State University of Ceara, Fortaleza 60714, CE, Brazil.ORCID 0000-0002-0994-6180
Joao Carvalho-de-SouzaDepartment of Physiology, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoeugenol is a phenylpropanoid that is commonly found in essential oils and has been commonly used as a flavoring agent in the culinary field and an anesthetic in fish. Yet despite its similarity to well-known eugenol, there is a lack of data regarding how isoeugenol would directly modulate neuronal excitability to interfere with pain signaling. Here, we studied the effects of isoeugenol on voltage-activated Na

Indexed as

EugenolSensory Receptor CellsVoltage-Gated Sodium ChannelsAnimalsGanglia, SpinalMalePatch-Clamp TechniquesRatsEugenolisoeugenolVoltage-Gated Sodium Channelsisoeugenollocal anesthetic mechanismphenylpropanoidssensory neuronsvoltage-gated sodium channels (VGSC)

Identifiers

PMID40869055
PMCPMC12386636

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.