Evidence map›Paper›PMID 40869080›Full record

ArticleInternational journal of molecular sciences2025

Interconnection of Gut Microbiome and Efficacy of Immune Checkpoint Inhibitors in Inoperable Non-Small-Cell Lung Cancer.

Fedor Moiseenko, Andrey Kechin, Maksim Koryukov, Ulyana Boyarskikh, Albina Gabina, Ani Oganesian, Sergey Belukhin, Maria Makarkina, Ekaterina Elsakova, Elizaveta Artemeva and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Fedor MoiseenkoSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.ORCID 0000-0003-2544-9042
Andrey KechinInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.ORCID 0000-0002-4822-0251
Maksim KoryukovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.ORCID 0000-0003-0223-7303
Ulyana BoyarskikhInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.ORCID 0000-0002-5660-2276
Albina GabinaSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Ani OganesianSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Sergey BelukhinSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Maria MakarkinaSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Ekaterina ElsakovaSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Elizaveta ArtemevaSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Alexander MyslikSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Nikita VolkovSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Alexey BogdanovSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Ekaterina KuliginaN.N. Petrov National Medical Research Center of Oncology, Ministry of Public Health of the Russian Federation, Leningradskaya Str. 68, 197758 St. Petersburg, Russia.ORCID 0000-0002-2396-6540
Svetlana AleksakhinaN.N. Petrov National Medical Research Center of Oncology, Ministry of Public Health of the Russian Federation, Leningradskaya Str. 68, 197758 St. Petersburg, Russia.
Aglaya IyevlevaN.N. Petrov National Medical Research Center of Oncology, Ministry of Public Health of the Russian Federation, Leningradskaya Str. 68, 197758 St. Petersburg, Russia.ORCID 0000-0001-5454-5186
Alexander IvantsovN.N. Petrov National Medical Research Center of Oncology, Ministry of Public Health of the Russian Federation, Leningradskaya Str. 68, 197758 St. Petersburg, Russia.
Andrey BogdanovSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.
Sergey SidorenkoFaculty of Oncology, North-Western State Medical University Named After I.I. Mechnikov, Kirochnaya Str. 41, 191015 St. Petersburg, Russia.ORCID 0000-0003-3550-7875
Vladimir GostevFaculty of Oncology, North-Western State Medical University Named After I.I. Mechnikov, Kirochnaya Str. 41, 191015 St. Petersburg, Russia.ORCID 0000-0002-3480-8089
Alexey KomissarovFederal State-Financed Institution Pediatric Research and Clinical Center for Infectious Diseases, the Federal Medical Biological Agency, Professor Popov Str. 9, 197022 St. Petersburg, Russia.ORCID 0000-0001-6981-7316
Vasilisa DudurichCenter of Genomic Technologies "Cerbalab", Bolshoy Prospekt V.O. 90-2, 199106 St. Petersburg, Russia.
Lavrenty DanilovCenter of Genomic Technologies "Cerbalab", Bolshoy Prospekt V.O. 90-2, 199106 St. Petersburg, Russia.
Evgeny ImyanitovN.N. Petrov National Medical Research Center of Oncology, Ministry of Public Health of the Russian Federation, Leningradskaya Str. 68, 197758 St. Petersburg, Russia.
Vladimir MoiseyenkoSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) Named After N.P. Napalkov, Leningradskaya Str. 68A, Litera A, 197758 St. Petersburg, Russia.

Funding

Russian state-funded project for ICBFM SB RAS 125041005115-5
6 · The paper itself

Abstract

The efficacy of immune checkpoint inhibitors (ICIs) in non-small-cell lung cancer (NSCLC) varies widely across patients. Growing evidence indicates that the gut microbiome, through its interaction with the tumor microenvironment, may influence the response to immunotherapy. To investigate this, we analyzed fecal and tumor samples from 63 patients with inoperable NSCLC undergoing ICI therapy. Based on microbiome profiling using 16S rRNA sequencing, patients were grouped according to treatment benefit, defined as progression-free survival (PFS) of six months or longer. Associations between α-diversity indices, microbial composition at the genus and phylum levels, and a composite Sum Index of Binary Abundance (SIBA) were examined in relation to clinical outcomes. Higher microbial α-diversity was linked to improved response to ICIs (

Indexed as

Carcinoma, Non-Small-Cell LungGastrointestinal MicrobiomeImmune Checkpoint InhibitorsLung NeoplasmsAgedFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16STreatment OutcomeTumor MicroenvironmentImmune Checkpoint InhibitorsRNA, Ribosomal, 16Simmune checkpoint inhibitorsimmunotherapymetagenomemicrobiomenon-small cell lung cancertumor microenvironmentα-diversity

Identifiers

PMID40869080
PMCPMC12386741

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.