Neutrophil Gelatinase-Associated Lipocalin: A Shared Early Biomarker of Remote Organ Dysfunction in Blast-Induced Extremity Trauma.

Cassie J Rowe, Uloma Nwaolu, Philip J Spreadborough, Thomas A Davis

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cassie J RoweDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0001-8067-8409

Uloma NwaoluDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Philip J SpreadboroughAcademic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham B15 2WB, UK.ORCID 0000-0002-9364-6657

Thomas A DavisDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-8076-6545

Funding

Congressionally Directed Medical Research Programs W81XWH1920032

6 · The paper itself

Abstract

Polytrauma is a critical global health concern characterized by immune dysregulation and a high risk of multiple organ dysfunction syndrome (MODS). Early molecular mechanisms linking trauma severity to organ injury are poorly understood. We used two rat blast-polytrauma models: a tourniquet-induced ischemia/reperfusion injury (tIRI) model and a non-ischemia/reperfusion injury (non-IRI) model. Naïve animals served as controls. RT-qPCR of 120 inflammatory genes in the lung, kidney, and liver, combined with STRING protein-protein interaction analysis, revealed distinct yet overlapping inflammatory gene signatures across all the organs. A core set of genes (

Indexed as

Blast InjuriesExtremitiesLipocalin-2Multiple Organ FailureAnimalsBiomarkersDisease Models, AnimalInflammationLiverMaleRatsRats, Sprague-DawleyReperfusion InjuryBiomarkersLcn2 protein, ratLipocalin-2inflammationischemia/reperfusion injurypolytraumaremote organ injurytourniquet

Identifiers

PMID40869116

DOI10.3390/ijms26167794

PMCPMC12386635

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.