Evidence map›Paper›PMID 40869128›Full record

ArticleInternational journal of molecular sciences2025

CD4

Xinyu Zhang, Junteng Zhou, Yu Kang, Xiaojing Chen, Zixuan Yang, Yingjing Xie, Ting Liu, Xiaojing Liu, Qing Zhang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyu ZhangDepartment of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.ORCID 0000-0002-9208-0778
Junteng ZhouDepartment of Health Management Center, General Practice Medical Center, West China Hospital of Sichuan University, Chengdu 610041, China.
Yu KangDepartment of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Xiaojing ChenDepartment of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.ORCID 0000-0003-1354-5053
Zixuan YangDepartment of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Yingjing XieDepartment of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Ting LiuDepartment of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Xiaojing LiuDepartment of Cardiology and Laboratory of Cardiovascular Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
Qing ZhangDepartment of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.ORCID 0000-0002-5652-4036

Funding

Foundation - "0 to 1" Innovative research project of Sichuan University 2023SCUH0063
6 · The paper itself

Abstract

Recent multiomics advancements have improved our understanding of immune dysregulation in dilated cardiomyopathy (DCM). However, specific immune cell subsets and their regulatory genes are still ambiguous. This study aimed to explore immune cell imbalances and regulatory genes in DCM, discover diagnostic biomarkers, and identify potential therapeutic targets. Immune cell infiltration in DCM patients was quantified via deconvolution algorithms and single-cell RNA sequencing. Flow cytometry validation in 40 DCM patients and 40 healthy controls confirmed a notable increase in CD4

Indexed as

Cardiomyopathy, DilatedCD4-Positive T-LymphocytesProtein Tyrosine Phosphatase, Non-Receptor Type 22T-Lymphocyte SubsetsAdultBiomarkersFemaleGene Expression ProfilingGene Regulatory NetworksHumansMaleMiddle AgedProtein Interaction MapsBiomarkersProtein Tyrosine Phosphatase, Non-Receptor Type 22PTPN22 protein, humanCD4+ T cellsdilated cardiomyopathygene expression profilingimmune dysregulationmachine learningPTPN22weighted gene coexpression network analysis

Identifiers

PMID40869128
PMCPMC12386803

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.