Evidence map›Paper›PMID 40869154›Full record

ArticleInternational journal of molecular sciences2025

Synergistic Antimicrobial Activity of BrSPR20-P1 Peptide and Silver Nanoparticles Against Pathogenic Bacteria.

Thanyamai Thongin, Somchai Sawatdee, Nuttapon Songnaka, Jumpei Uchiyama, Theanchai Wiwasuku, Teerapol Srichana, Titpawan Nakpheng, Apichart Atipairin

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Bioactive Potentials of Endophytic FungusInternational journal of microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thanyamai ThonginSchool of Pharmacy, Walailak University, Nakhon Si Thammarat 80161, Thailand.
Somchai SawatdeeSchool of Pharmacy, Walailak University, Nakhon Si Thammarat 80161, Thailand.ORCID 0000-0002-4845-1527
Nuttapon SongnakaSchool of Pharmacy, Walailak University, Nakhon Si Thammarat 80161, Thailand.ORCID 0000-0003-3333-1730
Jumpei UchiyamaDepartment of Bacteriology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.ORCID 0000-0003-0846-0100
Theanchai WiwasukuSchool of Science, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand.
Teerapol SrichanaDrug Delivery System Excellence Center and Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai 90112, Thailand.ORCID 0000-0002-4772-2276
Titpawan NakphengDrug Delivery System Excellence Center and Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai 90112, Thailand.
Apichart AtipairinSchool of Pharmacy, Walailak University, Nakhon Si Thammarat 80161, Thailand.ORCID 0000-0003-2280-6649

Funding

King Prajadhipok and Queen Rambhai Barni Memorial FoundationScholarships for High Potential Candidates to Enroll in Master Programs, Walailak University 01/2566Walailak University RSPG-WU-14/2566Walailak University Graduate Research Fund CGS-RF-2024/14Walailak University Graduate Scholarships 13/2566
6 · The paper itself

Abstract

Bacterial infection is a cause of life-threatening diseases. The emergence of antimicrobial-resistant bacteria exacerbates this situation, highlighting the need for the discovery of new antimicrobial agents. Our previous study identified a novel antimicrobial peptide, BrSPR20-P1 (P1), which showed potential activity against MRSA. Additionally, silver nanoparticles (AgNPs) exhibit broad-spectrum antibacterial activity, capable of killing multidrug-resistant bacteria. The combination of antimicrobial agents presents a novel strategy for combating these pathogens. This study aimed to evaluate the antibacterial activity of the combination of P1 and AgNPs. It revealed that the combinations showed synergy. The P1 and AgNP mixture at a concentration of 1 and 8 µg/mL (1:8) doubled the activity against

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesMetal NanoparticlesSilverDrug SynergismEscherichia coliHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesSilverantimicrobial peptideBrevibacillus sp. SPR20silver nanoparticlesynergistic effect

Identifiers

PMID40869154
PMCPMC12386432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.