Evidence map›Paper›PMID 40869183›Full record

ArticleInternational journal of molecular sciences2025

Association of Low Free T3 with Disease Presence and Activity in Ankylosing Spondylitis.

Enver Ciftel, Aleksandra Klisic, Bayram Kizilkaya, Osman Cure, Filiz Mercantepe, Sibel Mataraci Karakas, Ana Ninić

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Enver CiftelDepartment of Endocrinology and Metabolism, Sivas Numune Hospital, 58060 Sivas, Türkiye.ORCID 0000-0003-1431-5663
Aleksandra KlisicFaculty of Medicine, University of Montenegro, 81000 Podgorica, Montenegro.ORCID 0000-0001-7870-0996
Bayram KizilkayaDepartment of Internal Medicine, Recep Tayyip Erdogan University Training and Research Hospital, 53100 Rize, Türkiye.
Osman CureDepartment of Rheumatology, Faculty of Medicine, Recep Tayyip Erdogan University, 53100 Rize, Türkiye.ORCID 0000-0001-5848-6363
Filiz MercantepeDepartment of Endocrinology and Metabolism, Faculty of Medicine, Recep Tayyip Erdogan University, 53100 Rize, Türkiye.ORCID 0000-0002-4325-1534
Sibel Mataraci KarakasDepartment of Biochemistry, Faculty of Medicine, Recep Tayyip Erdogan University, 53100 Rize, Türkiye.ORCID 0000-0001-7147-5087
Ana NinićDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-3838-1606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by axial skeletal involvement and systemic metabolic changes. While inflammation is central to its pathophysiology, the potential role of thyroid hormones, particularly free triiodothyronine (FT3), in disease risk and activity remains underexplored. The objective of this study is to evaluate the relationship between serum FT3 levels and both the presence and clinical activity of AS, while also examining other endocrine-metabolic parameters. In this cross-sectional study, 120 AS patients and 117 healthy controls were assessed. Demographic, anthropometric, hematologic, and biochemical parameters were recorded. Disease activity was determined using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), with BASDAI ≥ 4 indicating active disease. Logistic regression models adjusting for age, sex, BMI, and other relevant covariates were applied to identify independent predictors. FT3 levels were significantly lower in AS patients compared to controls (3.25 [3.01-3.58] vs. 3.44 [3.16-3.69] pg/mL,

Indexed as

Spondylitis, AnkylosingTriiodothyronineAdultBiomarkersCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexBiomarkersTriiodothyronineankylosing spondylitisBASDAIdisease activityFT3inflammationmetabolic markersthyroid hormones

Identifiers

PMID40869183
PMCPMC12386563

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.