Evidence map›Paper›PMID 40869252›Full record

ReviewInternational journal of molecular sciences2025

VEXAS Syndrome: Genetics, Gender Differences, Clinical Insights, Diagnostic Pitfalls, and Emerging Therapies.

Salvatore Corrao, Marta Moschetti, Salvatore Scibetta, Luigi Calvo, Annarita Giardina, Ignazio Cangemi, Carmela Zizzo, Paolo Colomba, Giovanni Duro

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Salvatore CorraoDepartment of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, Italy.ORCID 0000-0001-5621-1374
Marta MoschettiInstitute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), 90146 Palermo, Italy.ORCID 0009-0008-2119-7988
Salvatore ScibettaDepartment of Internal Medicine, National Relevance and High Specialization Hospital Trust, ARNAS Civico, Di Cristina, Benfratelli, 90127 Palermo, Italy.
Luigi CalvoDepartment of Internal Medicine, National Relevance and High Specialization Hospital Trust, ARNAS Civico, Di Cristina, Benfratelli, 90127 Palermo, Italy.
Annarita GiardinaDepartment of Internal Medicine, National Relevance and High Specialization Hospital Trust, ARNAS Civico, Di Cristina, Benfratelli, 90127 Palermo, Italy.
Ignazio CangemiDepartment of Internal Medicine, National Relevance and High Specialization Hospital Trust, ARNAS Civico, Di Cristina, Benfratelli, 90127 Palermo, Italy.ORCID 0000-0002-9426-7798
Carmela ZizzoInstitute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), 90146 Palermo, Italy.
Paolo ColombaInstitute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), 90146 Palermo, Italy.ORCID 0000-0002-2470-7030
Giovanni DuroInstitute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), 90146 Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

VEXAS syndrome (Vacuoles, E1-enzyme, X-linked, Autoinflammation, and Somatic) is a recently identified late-onset autoinflammatory disorder characterized by a unique interplay between hematological and inflammatory manifestations. It results from somatic mutations in the

Indexed as

Erythema NodosumGenetic Diseases, X-LinkedUbiquitin-Activating EnzymesFemaleHumansMaleMutationMyelodysplastic SyndromesSkin Diseases, GeneticUBA1 protein, humanUbiquitin-Activating Enzymesclinical featureshematological and inflammatory manifestationslyonization affectstherapeutic approachesVEXAS syndromeX-linked pathology

Identifiers

PMID40869252
PMCPMC12386336

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.