Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Rommel Sánchez-HernándezDepartment of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Av. IPN 2508, San Pedro Zacatenco, Mexico City 07300, Mexico.ORCID 0000-0002-4008-4179
Daphne E Cruz-VillarrealDepartment of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Av. IPN 2508, San Pedro Zacatenco, Mexico City 07300, Mexico.ORCID 0009-0007-4484-5899
Alejandro Silva-PalaciosDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Belisario Domínguez Secc 16, Tlalpan, Mexico City 14080, Mexico.ORCID 0000-0002-8409-7967
Alejandra-María Zúñiga-MuñozDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Belisario Domínguez Secc 16, Tlalpan, Mexico City 14080, Mexico.
Elizabeth Soria-CastroDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Belisario Domínguez Secc 16, Tlalpan, Mexico City 14080, Mexico.
Carlos Sánchez-GaribayDepartment of Neuropathology, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Insurgentes Sur 3877, La Fama, Tlalpan, Mexico City 14269, Mexico.ORCID 0000-0002-0637-5239
Cecilia ZazuetaDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Belisario Domínguez Secc 16, Tlalpan, Mexico City 14080, Mexico.ORCID 0000-0003-1068-316X
J Alberto Olivares-ReyesDepartment of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Av. IPN 2508, San Pedro Zacatenco, Mexico City 07300, Mexico.ORCID 0000-0001-8389-9274
José-Antonio Arias-MontañoDepartment of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Av. IPN 2508, San Pedro Zacatenco, Mexico City 07300, Mexico.
Angélica RuedaDepartment of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Av. IPN 2508, San Pedro Zacatenco, Mexico City 07300, Mexico.ORCID 0000-0001-8749-8494
Funding
Consejo Nacional de Humanidades, Ciencias y Tecnologías A1-S-9082Consejo Nacional de Humanidades, Ciencias y Tecnologías CF-2023-G-446
6 · The paper itself
Abstract
Metabolic syndrome (MetS) is a worldwide problem affecting at least one-third of the population. MetS patients have increased cardiovascular risk associated with an abnormal β-adrenergic response; however, it is not clear how MetS affects the cardiac β-adrenergic system. We analyzed cardiac function and the β-adrenergic response in an experimental model of MetS in rats by recording pressure-volume (PV) loops via an open-chest approach and performed a biochemical characterization of the cardiac β-adrenergic system through ELISA, radioligand binding assays, and Western blotting. Microscopy was employed to evaluate cardiac hypertrophy, fibrosis, and ultrastructure. MetS rats exhibited cardiac dysfunction, evidenced by a reduced cardiac output and ejection fraction, not explained by heart hypertrophy or fibrosis. MetS rats also had an elevated susceptibility to lethal arrhythmia following intra-cardiac administration of the non-selective β-adrenergic agonist isoproterenol, suggesting alterations in the β-adrenergic system. The total serum adrenaline and noradrenaline levels were higher in the MetS animals than those in the control group. The radioligand binding assays indicated no change in the βAR density; however, the Western blot analyses revealed decreased levels of Gα
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.