ArticleInternational journal of molecular sciences2025
Assessment of the Significance of LP-PLA2, DPYSL2, and 8-OHdG in the Oncological Diagnosis of Patients with Brain Tumors and Vitamin D Deficiency.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Brain tumors are a significant medical problem. This study aimed to assess the potential significance of DPYSL2, 8-OHdG, and LP-PLA2 in the oncological diagnosis of patients with brain tumors who have a vitamin D deficiency. To this end, we measured the concentrations of LP-PLA2, DPYSL2, and 8-OHdG in 62 patients with different types of brain tumors who exhibited vitamin D deficiency. No significant variations were observed that would enable the differentiation of different types of intracranial tumors. However, we found a correlation between the concentrations of LP-PLA2 and DPYSL2 and tumor size (in the GBM and brain metastases groups). Additionally, we found a correlation between Lp-PLA2 and DPYSL2 levels in patients with GBM and brain metastases. In the control group, we identified correlations between 8-OHdG and Lp-PLA2, as well as between vitamin D levels and 8-OHdG. Further research is needed to fully comprehend the examined issues.
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