Spectroscopic Profile of Metabolome Dynamics During Rat Cortical Neuronal Differentiation.

Idália Almeida, Filipa Martins, Brian J Goodfellow, Alexandra Nunes, Sandra Rebelo

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Idália AlmeidaInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-0639-0666

Filipa MartinsInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-3277-1809

Brian J GoodfellowCICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.ORCID 0000-0003-3191-7121

Alexandra NunesInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-0595-5821

Sandra RebeloInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-5862-5797

Funding

Fundação para a Ciência e Tecnologia IBIMED Grant: Institute of Biomedicine (iBiMED)-UIDP/04501/2020 and UIDB/04501/2020Fundação para a Ciência e Tecnologia PhD fellowship 2021.07230.BD for I.A.Fundação para a Ciência e Tecnologia PTDC/BTM-TEC/3792/2021

6 · The paper itself

Abstract

Neuronal differentiation is a highly dynamic process marked by coordinated biochemical, structural, and metabolic changes. Rat primary cortical neurons are the preferred cell model to study this process as they can maintain their functional attributes, including functional synapses, and simulate the behavior of neuronal cells in vivo. In this study, we employed Fourier transform infrared (FTIR) spectroscopy to monitor the molecular transformations that occur during the differentiation of rat cortical neurons. Partial least squares regression (PLS-R) analysis from the 1800-1500 cm

Indexed as

Cell DifferentiationCerebral CortexMetabolomeNeuronsAnimalsCells, CulturedLeast-Squares AnalysisMetabolomicsRatsSpectroscopy, Fourier Transform Infraredcortical neuronsFTIRmetabolomicsneuronal differentiationproteomics

Identifiers

PMID40869348

DOI10.3390/ijms26168027

PMCPMC12386500

What Socratic holds

Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.