Evidence map›Paper›PMID 40869390›Full record

ArticleInternational journal of molecular sciences2025

Linking IFN-γ-Mediated Pathogenesis to ROCK-Targeted Therapy in a Scalable iPSCs-Based Vitiligo Model.

Toshiro Komatsu, Yupeng Dong, Takaharu Ikeda, Tamihiro Kawakami

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Regenerative biomaterials · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Toshiro KomatsuDivision of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Miyagi, Japan.
Yupeng DongDivision of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Miyagi, Japan.ORCID 0000-0002-8037-1455
Takaharu IkedaDivision of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Miyagi, Japan.
Tamihiro KawakamiDivision of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Miyagi, Japan.

Funding

the Japanese Society of Vitiligo. 20K08660
6 · The paper itself

Abstract

Vitiligo is a chronic autoimmune dermatosis defined by selective melanocyte depletion and patchy depigmentation. IFN-γ-driven recruitment of autoreactive CD8

Indexed as

Induced Pluripotent Stem CellsInterferon-gammarho-Associated KinasesVitiligoAmidesCells, CulturedCell SurvivalCoculture TechniquesHumansKeratinocytesMelanocytesPyridinesAmidesInterferon-gammaPyridinesrho-Associated KinasesbFGFco-culturedendritesET-1IFN-γiPSkeratinocytemelanocyteROCK inhibitorVitiligo

Identifiers

PMID40869390
PMCPMC12386722

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.