Evidence map›Paper›PMID 40869501›Full record

ReviewJournal of clinical medicine2025

Endoscopic Ultrasound-Directed Transgastric Endoscopic Retrograde Cholangiopancreatography (EDGE): Techniques, Outcomes and Safety Profiles.

Filippo Antonini, Giacomo Emanuele Maria Rizzo, Giuseppe Vanella, Lorenzo Fuccio, Andrea Lisotti, Michiel Bronswijk, Enrique Pérez-Cuadrado-Robles, Cecilia Binda, Stefano Mazza, Andrea Anderloni and 3 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Filippo AntoniniGastroenterology and Interventional Endoscopy Unit, Mazzoni Hospital AST Ascoli Piceno, 63100 Ascoli Piceno, Italy.ORCID 0000-0001-5453-3310
Giacomo Emanuele Maria RizzoGastroenterology and Endoscopy Unit, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, IRCCS-ISMETT, 90127 Palermo, Italy.ORCID 0000-0001-9335-6740
Giuseppe VanellaPancreatobiliary Endoscopy and EUS Division, San Raffaele Scientific Institute IRCCS, 20132 Milan, Italy.ORCID 0000-0001-7280-1761
Lorenzo FuccioDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0001-8618-2447
Andrea LisottiGastroenterology Unit, Hospital of Imola, University of Bologna, 40026 Bologna, Italy.ORCID 0000-0002-7724-7402
Michiel BronswijkGastroenterology and Hepatology, Imelda Hospital, 2820 Bonheiden, Belgium.ORCID 0000-0003-2039-5022
Enrique Pérez-Cuadrado-RoblesDepartment of Gastroenterology, Georges-Pompidou European Hospital, 75015 Paris, France.
Cecilia BindaGastroenterology and Digestive Endoscopy Unit, Forlì-Cesena Hospitals, AUSL Romagna, 47121 Forlì-Cesena, Italy.ORCID 0000-0003-1148-9684
Stefano MazzaGastroenterology and Digestive Endoscopy Unit, IRCCS Foundation Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0002-9068-3209
Andrea AnderloniGastroenterology and Digestive Endoscopy Unit, IRCCS Foundation Policlinico San Matteo, 27100 Pavia, Italy.
Carlo FabbriGastroenterology and Digestive Endoscopy Unit, Forlì-Cesena Hospitals, AUSL Romagna, 47121 Forlì-Cesena, Italy.ORCID 0000-0003-0670-9910
Ilaria TarantinoGastroenterology and Endoscopy Unit, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, IRCCS-ISMETT, 90127 Palermo, Italy.
I-EUS Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with Roux-en-Y gastric bypass (RYGB) are a significant challenge for endoscopic retrograde cholangiopancreatography (ERCP) due to the altered anatomy. Endoscopic ultrasound (EUS)-directed transgastric ERCP (EDGE) has emerged as a valuable alternative to standard methods like enteroscopy-assisted (EA-ERCP) and laparoscopy-assisted (LA-ERCP) ERCP. EDGE involves creating a temporary fistula between the gastric pouch and the excluded stomach under EUS guidance, typically using a lumen-apposing metal stent (LAMS). This allows a standard ERCP scope to access the second duodenum and the biliary tree with standard devices. Several studies have investigated the efficacy and safety of this approach, with variations in techniques such as suturing the LAMS to prevent migration. EDGE has demonstrated high technical success rates, and current evidence indicates that it can be performed safely, with acceptable rates of adverse events such as stent migration, bleeding, and perforation, making it the preferred option in referral centers. This comprehensive review aims to provide a concise evaluation of EDGE, its techniques, outcomes, and role in managing biliary and pancreatic disorders in RYGB patients.

Indexed as

EDGEendoscopic ultrasoundendoscopic ultrasound directed transgastric endoscopic retrograde cholangiopancreatographyendoscopyERCPEUSinterventionalLAMS

Identifiers

PMID40869501
PMCPMC12386752

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.