Evidence map›Paper›PMID 40869831›Full record

ArticleInternational journal of environmental research and public health2025

Benefits of Multimodal Exercise Intervention for BDNF and Cytokines Levels, Cognitive Function, and Motor Functionality in Alzheimer's Disease: A Preliminary Study.

Emmanuel Dias de Sousa Lopes, Flávia Gomes de Melo Coelho, Sheilla Tribess, Jonatas da Silva Catarino, Bruno Naves Ferreira, Marina de Melo Reis, Antônio Ribeiro Neto, Carlo José Freire Oliveira, Jair Sindra Virtuoso Júnior

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In one paragraph

Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emmanuel Dias de Sousa LopesCenter of Research in Physical Activity and Health, Federal University of Triângulo Mineiro, Uberaba 38061-500, Minas Gerais, Brazil.ORCID 0000-0002-2488-925X
Flávia Gomes de Melo CoelhoCenter of Research in Physical Activity and Health, Federal University of Triângulo Mineiro, Uberaba 38061-500, Minas Gerais, Brazil.
Sheilla TribessCenter of Research in Physical Activity and Health, Federal University of Triângulo Mineiro, Uberaba 38061-500, Minas Gerais, Brazil.
Jonatas da Silva CatarinoLaboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-350, Minas Gerais, Brazil.ORCID 0000-0002-6542-7406
Bruno Naves FerreiraCenter of Research in Physical Activity and Health, Federal University of Triângulo Mineiro, Uberaba 38061-500, Minas Gerais, Brazil.
Marina de Melo ReisCenter of Research in Physical Activity and Health, Federal University of Triângulo Mineiro, Uberaba 38061-500, Minas Gerais, Brazil.
Antônio Ribeiro NetoCenter of Research in Physical Activity and Health, Federal University of Triângulo Mineiro, Uberaba 38061-500, Minas Gerais, Brazil.ORCID 0000-0002-9112-2585
Carlo José Freire OliveiraLaboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-350, Minas Gerais, Brazil.ORCID 0000-0003-2211-7333
Jair Sindra Virtuoso JúniorCenter of Research in Physical Activity and Health, Federal University of Triângulo Mineiro, Uberaba 38061-500, Minas Gerais, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical exercise has been linked to improvements in motor and cognitive functions as well as to the modulation of neurotrophic and inflammatory factors, particularly in older adults. This aim of this study was to investigate the effects of a 12-week multimodal exercise program on cognitive function, motor performance, and plasma levels of brain-derived neurotrophic factor (BDNF) and cytokines in elderly individuals with Alzheimer's disease (AD).

methodsA non-randomized controlled trial design was employed, involving 23 participants aged 62 to 85 years diagnosed with mild to moderate AD. The intervention group (

methodsA non-randomized controlled trial design was used, involving 23 participants aged 62 to 85 years. Of these, 15 had a clinical diagnosis of mild to moderate AD and were allocated to either an intervention group (

resultsCompared to baseline, the intervention group demonstrated significant improvements in executive and attentional functions, as measured by the Frontal Assessment Battery (FAB) and Clock Drawing Test (CDT); mobility, balance, gait speed, and lower limb strength also improved (

conclusionsIn conclusion, the multimodal exercise program resulted in cognitive and motor benefits and positively modulated biomarkers related to neuroplasticity and inflammation, supporting its potential as a complementary intervention in elderly individuals with AD.

Indexed as

Alzheimer DiseaseBrain-Derived Neurotrophic FactorCognitionCytokinesExerciseExercise TherapyAgedAged, 80 and overFemaleHumansMaleMiddle AgedBDNF protein, humanBrain-Derived Neurotrophic FactorCytokinesAlzheimer’s diseaseBDNFcognitionelderlyphysical exercise

Identifiers

PMID40869831
PMCPMC12386868

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.