Evidence map›Paper›PMID 40869842›Full record

Trial reportInternational journal of environmental research and public health2025

A Resistance Training Program on Patients with Liver Cirrhosis: A Randomized Clinical Trial.

Amanda Brown, Ingrid Dias, Jefferson da Silva Novaes, Leandro Sant'Ana, Bruno Perez Felix, Fabio Cahuê, Anderson Brito-Azevedo, Michel Silva Reis, Agnaldo José Lopes, Verônica Salerno and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanda BrownFederal Institute of Southeast Minas Gerais-Campus Barbacena, Barbacena 36205-018, Brazil.
Ingrid DiasPostgraduate Program in Physical Education (PPGEF), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
Jefferson da Silva NovaesPostgraduate Program in Physical Education (PPGEF), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
Leandro Sant'AnaStrength Training Laboratory (LABFOR), Universidade Federal de Juiz de Fora, Juiz de Fora 36036-900, Brazil.ORCID 0000-0002-0156-4030
Bruno Perez FelixUndergraduate Program in Physical Therapy, IBMR University Center, Rio de Janeiro 22631-002, Brazil.
Fabio CahuêPostgraduate Program in Physical Education (PPGEF), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.ORCID 0000-0003-2273-8893
Anderson Brito-AzevedoLiver Transplant Unit, Adventista Silvestre Hospital, Rio de Janeiro 22241-220, Brazil.ORCID 0000-0002-3720-4387
Michel Silva ReisPostgraduate Program in Physical Education (PPGEF), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.ORCID 0000-0002-3817-0529
Agnaldo José LopesPostgraduate Program in Rehabilitation Science (PPGCR), Centro Universitário Augusto Motta, Rio de Janeiro 21032-060, Brazil.ORCID 0000-0001-8598-4878
Verônica SalernoPostgraduate Program in Physical Education (PPGEF), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.ORCID 0000-0002-4344-6710
Roberto SimãoPostgraduate Program in Physical Education (PPGEF), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
Estêvão Rios MonteiroPostgraduate Program in Physical Education (PPGEF), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.ORCID 0000-0003-1866-553X
Renata de Mello PerezFaculty of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21044-020, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCirrhosis represents an advanced stage of hepatic fibrosis, and the metabolic changes resulting from liver dysfunction can cause impairment in physical capacity and quality of life. This study aimed to evaluate the effect of 12 weeks of resistance exercise on inflammatory markers, oxidative stress, physical conditioning, and quality of life in patients with liver cirrhosis.

methodsA total of 38 patients paired in the exercise (EG) and control (CG) groups participated in this study. The EG submitted to two weekly sessions of a program composed of resistance exercises. We evaluated the inflammatory markers (IL-6, IL-10, and TNF-α), oxidative stress (carbonylated protein, total thiols, enzyme superoxide dismutase, and catalase activity), body composition, handgrip strength (HGS), total volume of training, cardiorespiratory capacity (VO

resultsRegarding the EG, when comparing the follow-up period to the baseline, significant differences (

conclusionsIn patients with liver cirrhosis, a resistance exercise program improved physical fitness and quality of life, without adverse events. In addition, it seems that this type of training can bring some benefit to the inflammatory profile and oxidative stress of this population.

Indexed as

Liver CirrhosisResistance TrainingAdultAgedBiomarkersFemaleHand StrengthHumansMaleMiddle AgedOxidative StressQuality of LifeBiomarkersliver cirrhosismuscle strengthphysical exercisequality of life

Identifiers

PMID40869842
PMCPMC12386610

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.