Evidence map›Paper›PMID 40869906›Full record

ArticleGenes2025

Association of

Iulia Andreea Badea, Lavinia Carmen Daba, Nicoleta Leopa, Irinel Raluca Parepa, Sorina Ispas, Mihaela Botnarciuc

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iulia Andreea BadeaFaculty of Medicine, Ovidius University, 900470 Constanta, Romania.ORCID 0009-0008-8202-0246
Lavinia Carmen DabaFaculty of Medicine, Ovidius University, 900470 Constanta, Romania.
Nicoleta LeopaDepartment of General Surgery, Emergency Hospital of Constanța, 900591 Constanta, Romania.
Irinel Raluca ParepaFaculty of Medicine, Ovidius University, 900470 Constanta, Romania.
Sorina IspasFaculty of Medicine, Ovidius University, 900470 Constanta, Romania.
Mihaela BotnarciucDepartment of General Surgery, Emergency Hospital of Constanța, 900591 Constanta, Romania.ORCID 0009-0004-3956-0440

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial ischemia remains a major cause of morbidity and mortality worldwide. Although traditional risk factors are well-established, genetic predisposition-particularly involving

methodsThis study included 69 adult patients with first-episode myocardial ischemia and 55 healthy controls, matched by age and sex. Participants were recruited from southeastern Romania between 2023 and 2025. Clinical data-such as blood pressure, body mass index, smoking, and alcohol consumption-were recorded. Genotyping for

resultsA significantly higher frequency of homozygous mutant genotypes was observed in patients with myocardial ischemia. The TT genotype of

conclusionsOur findings indicate a strong association between

Indexed as

Methylenetetrahydrofolate Reductase (NADPH2)Myocardial IschemiaPolymorphism, Single NucleotideAdultAgedCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedRisk FactorsRomaniaMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanA1298CC677Tgenetic susceptibilityMTHFR polymorphismmyocardial ischemia

Identifiers

PMID40869906
PMCPMC12385730

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.