Evidence map›Paper›PMID 40870389›Full record

ReviewMedicina (Kaunas, Lithuania)2025

Multidisciplinary Postoperative Ileus Management: A Narrative Review.

Sun Yu, Katrina Kerolus, Zhaosheng Jin, Sandi Bajrami, Paula Denoya, Sergio D Bergese

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Incidence and outcomes of postoperative paralytic ileus after cytoreductive surgery with HIPEC: A population-based study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sun YuDepartment of Surgery, Stony Brook University Renaissance School of Medicine, Stony Brook, NY 11794, USA.
Katrina KerolusDepartment of Anesthesiology, Stony Brook University Renaissance School of Medicine, Stony Brook, NY 11794, USA.
Zhaosheng JinDepartment of Anesthesiology, Stony Brook University Renaissance School of Medicine, Stony Brook, NY 11794, USA.ORCID 0000-0002-2495-7048
Sandi BajramiRenaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Paula DenoyaDepartment of Surgery, Stony Brook University Renaissance School of Medicine, Stony Brook, NY 11794, USA.ORCID 0000-0001-8437-7793
Sergio D BergeseDepartment of Anesthesiology, Stony Brook University Renaissance School of Medicine, Stony Brook, NY 11794, USA.ORCID 0000-0001-5641-5908

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative ileus is a prolonged impairment of gastrointestinal motility following surgical procedures. This often leads to increased morbidity, extended hospital stays, and high healthcare expenditures. In this review, we discuss the pathophysiology underlying postoperative ileus, its epidemiology, and perioperative management strategies. Patient characteristics, as well as expected perioperative course, could be used to stratify the risks of postoperative ileus. Preventive measures hinge upon a multimodal approach, minimally invasive surgical techniques, fluid management, early postoperative ambulation, and opioid-sparing analgesia strategies. Adjuvant interventions such as alvimopan, caffeine, and chewing gum have demonstrated efficacy in modulating the neurogenic and inflammatory components of postoperative ileus. Minimally invasive approaches, comprehensive perioperative management, and adjuvant therapies hold promise for prevention. Current management relies heavily on supportive care, underscoring the need for research into the underlying neurogenic and inflammatory mechanisms to guide the development of targeted treatments.

Indexed as

IleusPostoperative ComplicationsHumansenhanced recovery pathwaysgastric motilityneurogenic inflammationopioid-sparing analgesiaperioperative managementpostoperative ileussurgical outcomes

Identifiers

PMID40870389
PMCPMC12388418

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.