Evidence map›Paper›PMID 40871504›Full record

ArticleMolecules (Basel, Switzerland)2025

Mode of Action of Toxin 6-Hydroxydopamine in SH-SY5Y Using NMR Metabolomics.

Roktima Tamuli, George D Mellick, Horst Joachim Schirra, Yunjiang Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roktima TamuliInstitute for Biomedicine and Glycomics, Griffith University, Nathan, QLD 4111, Australia.
George D MellickInstitute for Biomedicine and Glycomics, Griffith University, Nathan, QLD 4111, Australia.
Horst Joachim SchirraInstitute for Biomedicine and Glycomics, Griffith University, Nathan, QLD 4111, Australia.ORCID 0000-0002-7541-246X
Yunjiang FengInstitute for Biomedicine and Glycomics, Griffith University, Nathan, QLD 4111, Australia.ORCID 0000-0003-2412-1213

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study used NMR-based metabolomics to investigate the mode of action (MoA) of 6-hydroxydopamine (6-OHDA) toxicity in the SH-SY5Y neuroblastoma cell model. 6-OHDA, a structural analogue of dopamine, has been used to create a Parkinson's disease model since 1968. Its selective uptake via catecholaminergic transporters leads to intracellular oxidative stress and mitochondrial dysfunction. SH-SY5Y cells were treated with 6-OHDA at its IC

Indexed as

MetabolomeMetabolomicsOxidopamineCell Line, TumorEnergy MetabolismHumansMagnetic Resonance SpectroscopyMembrane Potential, MitochondrialMitochondriaOxidative StressReactive Oxygen SpeciesOxidopamineReactive Oxygen Species6-OHDAETCNMR metabolomicsROSSH-SY5Y

Identifiers

PMID40871504
PMCPMC12388602

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.