Evidence map›Paper›PMID 40871578›Full record

ArticleMolecules (Basel, Switzerland)2025

Preclinical Evaluation of 2-Aminobenzothiazole Derivatives: In Silico, In Vitro, and Preliminary In Vivo Studies as Diabetic Treatments and Their Complications.

Natalia Reyes-Vallejo, Miguel Valdes, Adelfo Reyes-Ramírez, Juan Andres Alvarado-Salazar, Alejandro Cruz, Erik Andrade-Jorge, Jessica Elena Mendieta-Wejebe

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalia Reyes-VallejoLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politcnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0009-0005-9378-4063
Miguel ValdesLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politcnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0001-7401-303X
Adelfo Reyes-RamírezLaboratorio de Síntesis Farmacéutica, Unidad Multidisciplinaria de Investigación Experimental Zaragoza, FES Zaragoza-Universidad Nacional Autonoma de México, Campus II. Batalla 5 de Mayo s/n, Ejército de Oriente Zona Peñón, Iztapalapa, Mexico City 09230, Mexico.ORCID 0000-0002-6796-6075
Juan Andres Alvarado-SalazarLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politcnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0002-6461-957X
Alejandro CruzLaboratorio de Química Supramolecular y Nanociencias, Unidad Profesional Interdisciplinaria de Biotecnología, Departamento de Ciencias Básicas, Instituto Politécnico Nacional, Av. Acueducto s/n, Colonia Barrio La Laguna Ticomán, Mexico City 07340, Mexico.ORCID 0000-0002-6255-9112
Erik Andrade-JorgeLaboratorio de Investigación en Bioquímica, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0003-0745-0090
Jessica Elena Mendieta-WejebeLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politcnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0002-2471-9875

Funding

Instituto Poitécnico Nacional SIPMULTI20242297Instituto Politécnico Nacional SIP20250177Instituto Politécnico Naconal SIPMULTI20240101
6 · The paper itself

Abstract

Type 2 diabetes is a multifactorial disease characterized by chronic hyperglycemia, insulin resistance, oxidative stress, inflammation, and dyslipidemia, factors that contribute to the development of long-term complications. In this context, the 2-aminobenzothiazole scaffold has emerged as a promising candidate due to its broad spectrum of biological properties. In this study, we performed a multidisciplinary evaluation of benzothiazole derivatives (

Indexed as

BenzothiazolesDiabetes ComplicationsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Hypoglycemic AgentsAldehyde ReductaseAnimalsComputer SimulationDrug Evaluation, PreclinicalHumansMaleMolecular Docking SimulationPPAR gammaRatsRats, WistarAldehyde ReductaseBenzothiazolesHypoglycemic AgentsPPAR gammaaldose reductaseantihyperglycemicbenzothiazolemolecular dockingPPAR-γ

Identifiers

PMID40871578
PMCPMC12388506

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.