Evidence map›Paper›PMID 40872807›Full record

ArticleViruses2025

Hemophagocytic Lymphohistiocytosis Gene Variants in Severe COVID-19 Cytokine Storm Syndrome.

Abhishek Kamath, Mingce Zhang, Devin M Absher, Lesley E Jackson, Walter Winn Chatham, Randy Q Cron

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abhishek KamathHeersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL 35233, USA.ORCID 0000-0001-6408-3253
Mingce ZhangDivision of Rheumatology, Children's of Alabama, Birmingham, AL 35233, USA.
Devin M AbsherKaiser Permanente Bernard J. Tyson School of Medicine, Oakland, CA 94612, USA.ORCID 0000-0003-4405-1646
Lesley E JacksonDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham (UAB), Birmingham, AL 35233, USA.ORCID 0000-0002-9373-7620
Walter Winn ChathamDivision of Rheumatology, University of Nevada, Las Vegas (UNLV), Las Vegas, NV 89102, USA.ORCID 0000-0001-6452-2113
Randy Q CronHeersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL 35233, USA.ORCID 0000-0003-2661-3086

Funding

Histiocytosis Association n/aKaul Pediatric Research Institute n/aRheumatology Research Foundation n/aSwedish Orphan Biovitrum, Inc. n/aUniversity of Alabama at Birmingham Heersink School of Medicine and Precision Medicine Institute n/a
6 · The paper itself

Abstract

Severe COVID-19 infection resulting in hospitalization shares features with cytokine storm syndromes (CSSs) such as hemophagocytic lymphohistiocytosis (HLH). Various published criteria were explored to define CSS among patients (n = 32) enrolled in a COVID-19 clinical trial. None of the patients met HLH-04 or HScore criteria, but the ferritin to erythrocyte sedimentation rate (ferritin-ESR) ratio and the COVID-19 cytokine storm score (CSs) identified 84% and 81% of patients, respectively. As 30-40% of patients in published secondary HLH cohorts possess rare heterozygous mutations in familial HLH (fHLH) genes, whole genome sequencing was undertaken to explore immunologic gene mutation associations among 20 patients enrolled in the trial. Rare mutations in fHLH genes were identified in 6 patients (30%), and 4 patients (20%) possessed rare mutations in

Indexed as

COVID-19Cytokine Release SyndromeLymphohistiocytosis, HemophagocyticAdultAgedFemaleFerritinsHumansKiller Cells, NaturalMaleMiddle AgedMutationSARS-CoV-2Whole Genome SequencingFerritinsanakinraclinical trialCOVID-19cytokine storm syndromecytolysisDOCK8geneticshemophagocytic lymphohistiocytosisnatural killer cellSARS-CoV-2

Identifiers

PMID40872807
PMCPMC12390453

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.