Evidence map›Paper›PMID 40872814›Full record

ReviewViruses2025

Updates on Recent Advancements in Hepatitis D Virus Treatment.

Ali Emre Bardak, Nazli Begum Ozturk, Merve Gurakar, Lynette Sequeira, Eda Yildiz, Enis Hikmet Ozmert, Ramazan Idilman, Ahmet Gurakar

Abstract readReview
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ali Emre BardakDepartment of Medicine, Boston Medical Center-Brighton, Boston, MA 02135, USA.
Nazli Begum OzturkDivision of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.ORCID 0000-0002-8595-1838
Merve GurakarDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-4671-3300
Lynette SequeiraDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-5246-2317
Eda YildizDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-3250-4345
Enis Hikmet OzmertDepartment of Surgery, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-6510-305X
Ramazan IdilmanDepartment of Gastroenterology, Ankara University School of Medicine, Ankara 06230, Turkey.ORCID 0000-0001-8840-5472
Ahmet GurakarDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2221-9148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis D virus (HDV) infection remains a major cause of severe liver disease among hepatitis B virus (HBV)-infected patients, contributing to accelerated progression to cirrhosis and hepatocellular carcinoma. Pegylated interferon-α remains the first-line therapy for chronic HDV infection in most cases. However, despite its approval for HBV and hepatitis C virus (HCV) infections, its use in HDV is largely driven by a lack of other options and is constrained by its limited efficacy, suboptimal durability of response, and a substantial side effect profile. Meanwhile, bulevirtide, an entry inhibitor, became the first agent to be approved for use in chronic HDV infections by the European Medicines Agency (EMA), and several other therapies are currently being investigated as well. In this review, we provide updates on recent advancements in HDV treatment and novel therapies.

Indexed as

Antiviral AgentsHepatitis DHepatitis D, ChronicHepatitis Delta VirusHumansAntiviral Agentsantisense oligonucleotidebulevirtideHDVhepatitis D virusinterferon lambdalonafarnibnucleic acid polymersmall interfering RNA

Identifiers

PMID40872814
PMCPMC12390690

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.