Evidence map›Paper›PMID 40872872›Full record

ArticleVaccines2025

Polymorphism in IFNλ Can Impact the Immune/Inflammatory Response to COVID-19 Vaccination in Older CMV-Seropositive Adults.

Ariane Nardy, Fernanda Rodrigues Monteiro, Brenda Rodrigues Silva, Jônatas Bussador do Amaral, Danielle Bruna Leal Oliveira, Érika Donizetti de Oliveira Cândido, Edison Luiz Durigon, Andressa Simões Aguiar, Guilherme Pereira Scagion, Vanessa Nascimento Chalup and 5 more

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Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ariane NardyPost-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04743-030, SP, Brazil.
Fernanda Rodrigues MonteiroPost-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04743-030, SP, Brazil.
Brenda Rodrigues SilvaPost-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04743-030, SP, Brazil.
Jônatas Bussador do AmaralENT Research Laboratory, Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, SP, Brazil.ORCID 0000-0001-5819-0474
Danielle Bruna Leal OliveiraHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.ORCID 0000-0002-0534-0886
Érika Donizetti de Oliveira CândidoDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0002-9132-569X
Edison Luiz DurigonDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0003-4898-6553
Andressa Simões AguiarDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.
Guilherme Pereira ScagionDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0003-0160-9515
Vanessa Nascimento ChalupDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.
Guilherme Eustáquio FurtadoPolytechnic University of Coimbra (IPC), Rua da Misericórdia, Lagar dos Cortiços-S. Martinho do Bispo, 3045-093 Coimbra, Portugal.ORCID 0000-0001-8327-1567
Marina Tiemi ShioPost-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04743-030, SP, Brazil.
Carolina Nunes FrançaPost-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04743-030, SP, Brazil.
Luiz Henrique da Silva NaliPost-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04743-030, SP, Brazil.
André Luis Lacerda BachiPost-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04743-030, SP, Brazil.ORCID 0000-0001-8266-1416

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo #2020/11561-7 / #2019/14115-0 / 2022/02030-3National Council for Scientific and Technological Development #305008/2022-6
6 · The paper itself

Abstract

backgroundChronic cytomegalovirus (CMV) infection may favor the development of immunosenescence and inflammation that impair vaccine responses, including COVID-19. In addition, the polymorphism of the interferon-lambda gene (IFNλ) affects COVID-19 immune responses in older adults.

objectiveWe aimed to investigate the impact of IFNλ polymorphism (

methodsBlood samples from 42 CMV-seropositive older adults (73.7 ± 4.5 years) were collected before and 30 days after immunization with a second dose of the CoronaVac vaccine to evaluate the immune/inflammatory response.

resultsAt genotyping, 20 subjects were homozygous for the C/C alleles (Allele-1 group), 5 were homozygous for the T/T Alleles (Allele-2 group), and 17 were heterozygous (C/T, Alleles-1/2 group). The Allele-1 group showed higher IgG levels for COVID-19 (

conclusionCMV-seropositivity in older adults who had Allele-1 could lead to an unbalanced systemic inflammatory state, which may impair their antibody response to COVID-19 vaccination compared to other volunteer groups.

Indexed as

cytokinesimmunoglobulinsimmunophenotypingimmunosenescenceinflammagingSARS-CoV-2

Identifiers

PMID40872872
PMCPMC12390593

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.