ArticleFrontiers in immunology2025
Antimicrobial and immunomodulatory activity of natural bioactive compounds - an
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Manuka honey as a multifunctional therapeutic against Helicobacter pylori: from chemical profiling to in vitro potency and in vivo gastroprotective efficacy.BMC complementary medicine and therapies · 2026Article
- Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Natural bioactive compounds such as terpenoids and phenolic acids have emerged as promising agents in dermatological research due to their proven antioxidant, antimicrobial and anti-inflammatory properties. Hidradenitis Suppurativa (HS), a chronic inflammatory condition, presents a therapeutic challenge that could benefit from innovative approaches harnessing these natural compounds. Objective: The present study aimed to evaluate the antimicrobial and immunomodulatory effects of phytoconstituent agents (FCs) including Gallic Acid (GA), α-Terpineol (αT) and Nerolidol (N), both individually and in combinations. The potential of these compounds to enhance immune regulation and inhibit biofilm development in HS-related pathogen was explored through Methods: Phytocompounds (FCs) (GA, αT and N) were obtained by solubilization in dimethyl sulfoxide (DMSO) at an initial concentration of 10 mg/mL and tested against standard and clinical strains of HS-associated pathogens. Additionally, Lactic Acid Bacterial (LAB) strains isolated from normal microbiota, dental plaque and lactic fermented foods were assessed for their antimicrobial, anti-biofilm and immunomodulatory effect, using both qualitative and quantitative assays. The immunomodulatory properties were analyzed using macrophages differentiated from THP-1 human monocytic cells. Cytokine modulation was measured via Enzyme-Linked Immunosorbent Assay (ELISA). Results: The combination of α-terpineol and nerolidol demonstrated potent antimicrobial activity and markedly inhibiting biofilm development, particularly against Gram-positive bacterial strains. A significant modulation of the inflammatory response, including enhanced IL-10 induction, was observed when Conclusions: These findings underscore the potential of natural bioactive compounds and their combinations as promising candidates for further investigation in managing skin infections and inflammation-related disorders, including HS. Future studies are essential to optimize formulations, evaluate compound stability, cytotoxicity and skin penetration and establish efficacy
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.