Evidence map›Paper›PMID 40873593›Full record

ArticleAnalytical science advances2025

Rapid Dereplication of Bioactive Compounds in Plant and Food Extracts Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry.

Naheed Akhtar, Adeeba Khadim, Syed Usama Yaseen Jeelani, Bibi Zareena, Arslan Ali, Jalal Uddin, Hesham R El-Seedi, Satyajit D Sarker, Muhammad Ramzan, Syed Ghulam Musharraf

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Article in Analytical science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Phytochemistry and Pharmacological Potential of the GenusPharmaceuticals (Basel, Switzerland) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naheed AkhtarH.E.J. Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan.
Adeeba KhadimH.E.J. Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan.
Syed Usama Yaseen JeelaniH.E.J. Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan.ORCID https://orcid.org/0000-0002-6883-8489
Bibi ZareenaH.E.J. Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan.
Arslan AliDr. Panjwani Center For Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan.
Jalal UddinDepartment of Pharmaceutical Chemistry College of Pharmacy King Khalid University Asir Saudi Arabia.ORCID https://orcid.org/0000-0002-8613-4493
Hesham R El-SeediDepartment of Chemistry Faculty of Science Islamic University of Madinah Madinah Saudi Arabia.
Satyajit D SarkerCentre For Natural Products Discovery School of Pharmacy and Biomolecular Sciences Faculty of Science Liverpool John Moores University Liverpool UK.
Muhammad RamzanH.E.J. Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan.
Syed Ghulam MusharrafH.E.J. Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan.ORCID https://orcid.org/0000-0003-2026-3302

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-throughput screening and identification of common phytochemicals are crucial for lead optimization, drug development and investigation of metabolic pathways in complex herbal extracts. The available databases contain a huge number of compounds, making it challenging and time-consuming to dereplicate valuable compounds. Therefore, the current study aimed to develop an in-house mass spectral library for the rapid dereplication of 31 commonly occurring natural products from different classes using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). A total of 31 standards were grouped into two different pools, and each pool was analysed under uniformly optimized conditions in positive ionization mode. A pooling strategy on the basis of log

Indexed as

dereplicationflavonoidsLC–HR–ESI–MS/MStandem mass spectral librarytriterpenes

Identifiers

PMID40873593
PMCPMC12380011

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.