Observational studyFrontiers in endocrinology2025
Sex differences in the association between atherogenic index of plasma and progression from normoglycemia to prediabetes: evidence from a 5-year large-scale retrospective cohort study.
Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- BMI-specific nonlinear associations and threshold effects of the atherogenic index of plasma on incident prediabetes: insights from 100473 Chinese adults.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Currently, there is limited research on the relationship between the atherogenic index of plasma (AIP) and the risk of prediabetes (pre-DM). This study aims to explore the potential link between AIP and the risk of progression from normoglycemia to pre-DM. Methods: In this retrospective cohort analysis, a total of 8,295 individuals receiving routine medical examinations at Kuichong People's Hospital in Shenzhen between January 2018 and December 2023 were enrolled. The Cox proportional hazards regression model assessed the association between AIP and the risk of progression from normoglycemia to pre-DM, with restricted cubic splines functions used to assess non-linear relationships. Additionally, a competing risk Cox model was used, treating the progression from normoglycemia to diabetes (DM) as a competing event for pre-DM. Finally, the subgroup and sensitivity analyses confirmed the robustness of the findings. Results: After multivariable adjustment, each 0.1-unit increase in AIP was associated with an 11.5% increase in the risk of progression from normoglycemia to pre-DM [hazard ratio (HR) = 1.115; 95% confidence interval (CI): 1.065-1.167]. The competing risk Cox model showed that the sub-distribution hazard ratio for the association between AIP and the risk of pre-DM was 1.09 (95% CI: 1.04-1.14). Additionally, a non-linear association was observed in men, with an inflection point at 0.513. Below this threshold, each 0.1-unit increase in AIP was associated with an HR of 1.204 (95% CI: 1.098-1.321). In women, the relationship was linear. Conclusion: This study demonstrated that elevated AIP was positively associated with the risk of progression from normoglycemia to pre-DM, with a significant sex difference in this relationship. This provides a reference for individualized risk stratification and management strategies for different sex populations and offers new perspectives for optimizing strategies to prevent pre-DM and DM.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.