Evidence map›Paper›PMID 40874567›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2025

Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 d of bed rest.

Kathryn Culliton, Gerd Melkus, Adnan Sheikh, Tammy Liu, Alain Berthiaume, Gabi Armbrecht, Guy Trudel

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathryn CullitonBone and Joint Research Laboratory, Inflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.
Gerd MelkusDepartment of Radiology, Radiation Oncology and Medical Physics, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Adnan SheikhDepartment of Radiology, University of British Columbia, Vancouver, BC, V6T 1Z2, Canada.
Tammy LiuBone and Joint Research Laboratory, Inflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.
Alain BerthiaumeDepartment of Radiology, Radiation Oncology and Medical Physics, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Gabi ArmbrechtDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, 10117, Germany.
Guy TrudelBone and Joint Research Laboratory, Inflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.ORCID 0000-0001-5254-4294

Funding

Canadian Space Agency 18FAOTTC07German Aerospace Center, the European Space Agency 4000113871/15/NL/PGGerman Aerospace Centre FKZ50WB1521NASA 80JSC018P0078
6 · The paper itself

Abstract

Inactivity has been associated with increased bone marrow adipose tissue (BMAT) and bone loss. Artificial gravity (AG) may prevent these complications. This randomized controlled trial investigated the effectiveness of AG at 2 g at the feet to prevent lumbar vertebral BMAT accumulation and bone loss. Twenty-four participants (16 male, 8 female) were bedridden for 60 d at 6° head down tilt. They were randomly assigned to bedrest only (n = 8), continuous supine centrifugation (cAG; 30 min/d), or intermittent supine centrifugation (iAG; 6 bouts of 5 min/d). Serial 3T magnetic resonance (MR) measured BMAT while DXA measured BMD in the lumbar vertebrae before, during, and after bedrest. After 60 d of bedrest, vertebral BMAT was higher in controls, +3.93% (95% CI: -0.28 to 8.14), compared to cAG and iAG interventions. After 60 d of bedrest, male controls BMAT increased 5.81% (95% CI: 2.01 to 9.61) compared to -1.35% (95% CI: -5.74 to 3.04) and 1.23% (95% CI: -1.53 to 3.99) for male cAG and iAG participants, respectively. This difference between interventions was significant: X2(2) = 8.487, p = .014. In addition, while control male participants showed decreased BMD after 60 d of bedrest (-0.02 g/cm2; 95% CI: -0.05 to 0.00), the male participants receiving iAG showed no decrease in BMD during bedrest (0.00 g/cm2; 95% CI: -0.04 to 0.05). The modulation of BMAT was inversely correlated with BMD at the same vertebrae. Recreating an axial force vector mechanically on horizontalized participants prevented BMAT accumulation and demineralization. These findings suggest exploring technological advances to translate these clinical benefits to populations at risk of acute or chronic bone loss.

Indexed as

Adipose TissueBed RestBone and BonesBone MarrowGravity, AlteredAdultBone DensityFemaleHumansLumbar VertebraeMaleMiddle Agedartificial gravitybone marrow adipose tissuebone mineral densityinactivity

Identifiers

PMID40874567
PMCPMC12578298

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.