Evidence map›Paper›PMID 40875182›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026

Genomic insights on lung cancer risk: identifying new variants in Amazonian indigenous populations.

Bruno Melo Fernandes, Ana Caroline Alves da Costa, Natasha Monte, Kaio Evandro Cardoso Aguiar, Marcella Oliveira Monte Santo, Juliana Carla Gomes Rodrigues, Esdras Edgar Batista Pereira, João Farias Guerreiro, Sidney Emanuel Batista Dos Santos, Ândrea Ribeiro-Dos-Santos and 4 more

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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bruno Melo FernandesOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Ana Caroline Alves da CostaOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Natasha MonteOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Kaio Evandro Cardoso AguiarOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Marcella Oliveira Monte SantoOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Juliana Carla Gomes RodriguesOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Esdras Edgar Batista PereiraOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
João Farias GuerreiroOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Sidney Emanuel Batista Dos SantosOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Ândrea Ribeiro-Dos-SantosLaboratory of Human and Medical Genetics, Institute of Biological Science, Federal University of Pará, Belém, PA, 66077-830, Brazil.
André Maurício Ribeiro-Dos-SantosLaboratory of Human and Medical Genetics, Institute of Biological Science, Federal University of Pará, Belém, PA, 66077-830, Brazil.
Rommel Mario Rodríguez BurbanoHospital Ophir Loyola, Belém, PA, 66063-240, Brazil.
Marianne Rodrigues FernandesOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil.
Ney Pereira Carneiro Dos SantosOncology Research Center, Federal University of Pará, Belém, PA, 66073, Brazil. npcsantos.ufpa@gmail.com.ORCID http://orcid.org/0000-0001-8087-7037

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSignificant progress has been made in understanding and treating lung cancer. In the unique context of the Amazonian indigenous population, it is crucial to identify genetic variants in genes important for the risk of developing this cancer. There is a limitation of research on the broader genomic profile of indigenous peoples, especially in the Amazon region, in relation to lung cancer.

methodsWe evaluated the genomic profile of seven genes (KRAS, MET, RET, ERBB2, BRAF, PDL2 and PD-L1) related to lung cancer by sequencing the exome of 64 indigenous individuals belonging to 12 ethines from the Brazilian Amazon.

resultsOur study identified six variants of moderate impact already described in the literature, located in the RET, ERBB2, PDL2 and PD-L1 genes. We discovered six new variants unique to the Amazonian Amerindian population, one located in the KRAS gene, two located in the ERBB2 gene, and three located in the PDL2 gene.

conclusionsThe variants studied can potentially exert a significant influence on the heredity and carcinogenesis of lung cancer.

Indexed as

Genetic Predisposition to DiseaseIndians, South AmericanLung NeoplasmsBrazilFemaleGenetic VariationGenomicsHumansMaleMiddle AgedProto-Oncogene Proteins c-retProto-Oncogene Proteins c-retRET protein, humanGenetic variantsIndigenous populationsLung cancerPersonalized medicine

Identifiers

PMID40875182

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.