Evidence map›Paper›PMID 40875405›Full record

ReviewCirculation. Arrhythmia and electrophysiology2025

RYR2 Variants in Catecholaminergic Polymorphic Ventricular Tachycardia Patients: Insights From Protein Structure and Clinical Data.

Alexander Chang, Halil Beqaj, Leah Sittenfeld, Marco C Miotto, Haikel Dridi, Gloria Willson, Carolyn Martinez Jorge, Jaan Altosaar Li, Steven Reiken, Yang Liu and 5 more

Abstract readReview
In one paragraph

Review in Circulation. Arrhythmia and electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexander Chang *Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0009-0002-4273-2595
Halil Beqaj *Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0002-7980-7549
Leah Sittenfeld *Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0001-8349-0663
Marco C MiottoDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0001-8851-4863
Haikel DridiDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0001-9533-7367
Gloria WillsonAugustus C. Long Health Sciences Library, New York, NY (G.W.).ORCID 0000-0001-8664-1236
Carolyn Martinez JorgeDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0002-2930-1937
Jaan Altosaar LiDepartment of Biomedical Informatics, Columbia University Medical Center, New York, NY (J.A.L.).ORCID 0000-0003-1294-4159
Steven ReikenDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0002-5807-3574
Yang LiuDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0002-8343-4431
Zonglin DaiDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0002-4005-1297
Carl TchagouDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).
Sana ElsayedDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).
Steven O MarxDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (S.O.M.).ORCID 0000-0002-0577-6030
Andrew R MarksDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Vagelos College of Physicians and Surgeons, New York, NY (A.C., H.B., L.S., M.C.M., H.D., C.M.J., S.R., Y.L., Z.D., C.T., S.E., A.R.M.).ORCID 0000-0002-8057-1502

Funding

Molecular Basis of Sudden Cardiac DeathP01HL067849 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ARMIENTO, JEANINE M · 2001 to 2011
$15.0M
NHLBI NIH HHS P01 HL067849
6 · The paper itself

Abstract

backgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia, with pathogenic variants in the

methodsThis review cataloged clinical data on patients with

resultsIn 221 publications analyzed, 964 patients with CPVT (351 male, 463 female) were identified with 263

conclusionsThis study compiled a comprehensive data set of CPVT-associated

Indexed as

MutationRyanodine Receptor Calcium Release ChannelTachycardia, VentricularAdolescentChildFemaleGenetic Predisposition to DiseaseHumansMalePhenotypePolymorphic Catecholaminergic Ventricular TachycardiaRyanodine Receptor Calcium Release ChannelRyR2 protein, humanexonshumansincidencephenotypetreatment outcome

Identifiers

PMID40875405
PMCPMC12442783

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.