Evidence map›Paper›PMID 40875628›Full record

ArticlePloS one2025

Synergistic Treatment with Antiretrovirals and Laser Interstitial Thermal ThErapy (STARLITE) for unresectable glioblastoma: A phase 1 study protocol.

Manav Daftari, Christian K Ramsoomair, Daniel Aaronson, Deepa Seetharam, Emily A Andreae, Leonela Wright, Sunwoo Han, Jay Chandar, Victor Lu, Vaidya Govindarajan and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06428045 (Synergistic Treatment With Antiretrovirals and Laser Interstitial Thermal thErapy), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06428045 phase1recruitingnot on this map

Synergistic Treatment With Antiretrovirals and Laser Interstitial Thermal thErapy (STARLITE) for Unresectable High-Grade Gliomas: A Phase 1 Study

TypeinterventionalSponsorUniversity of MiamiRan2025 to 2030Enrolled24ConditionsHigh Grade GliomaArmsMagnetic Resonance (MR)-guided Laser Interstitial Thermal Therapy (LITT), Abacavir, Lamivudine, Ritonavir, Temozolomide
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Manav DaftariSection of Virology and Immunotherapy, Department of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.ORCID https://orcid.org/0009-0002-4206-6262
Christian K RamsoomairSection of Virology and Immunotherapy, Department of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Daniel AaronsonDepartment of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Deepa SeetharamSection of Virology and Immunotherapy, Department of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Emily A AndreaeProtocol Development Unit, Sylvester Comprehensive Cancer Center, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Leonela WrightDepartment of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Sunwoo HanBiostatistics and Bioinformatics Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Jay ChandarSection of Virology and Immunotherapy, Department of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Victor LuSection of Virology and Immunotherapy, Department of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Vaidya GovindarajanSection of Virology and Immunotherapy, Department of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Michael E IvanDepartment of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Ricardo J KomotarDepartment of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Macarena de la FuenteNeuro-Oncology Division, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.
Ashish H ShahSection of Virology and Immunotherapy, Department of Neurosurgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America.

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
NCI NIH HHS P30 CA240139
6 · The paper itself

Abstract

trial registrationThis clinical trial is registered on ClinicalTrials.gov (NCT06428045). The authors confirm that all ongoing and related trials for this intervention are registered.

Indexed as

Anti-Retroviral AgentsBrain NeoplasmsGlioblastomaLaser TherapyClinical Trials, Phase I as TopicCombined Modality TherapyFemaleHumansMaleMiddle AgedAnti-Retroviral Agents

Identifiers

PMID40875628
PMCPMC12393708

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.