ArticleBMJ open2025
Association of a healthy lifestyle with mortality risk among individuals with osteoarthritis: a prospective cohort study of the UK Biobank.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation.Journal of translational medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis is common and often coexists with other chronic conditions, which may contribute to increased all-cause mortality. Maintaining a healthy lifestyle contributes to increased longevity; however, considering physical functions and physiological conditions of patients with osteoarthritis differ from the general population, the impact of maintaining a healthy lifestyle in these patients remains uncertain, which poses a challenge to implementing-related interventions in this population. This study aims to examine the association between healthy lifestyle factors and mortality in individuals with osteoarthritis.
methodsThis cohort study enrolled 52 973 participants from the UK Biobank who met the criteria for osteoarthritis as defined via hospitalisation or primary care records. Seven lifestyle factors, consisting of smoking, alcohol intake, physical activity, diet, television watching time, sleep duration and social connection, were included. HRs (with 95% CIs) for total and cause-specific mortality were estimated by Cox proportional hazards regression models.
resultsA total of 4637 deaths were recorded during the follow-up period. Seven healthy lifestyle factors were all independently associated with a low mortality risk. When compared with participants meeting only 0-2 healthy lifestyle criteria, the adjusted HRs (95% CI) for those adhering to 3-7 factors were 0.70 (0.62 to 0.78), 0.60 (0.54 to 0.67), 0.49 (0.44 to 0.54), 0.46 (0.41 to 0.52) and 0.42 (0.36 to 0.49), respectively (
conclusionsAdherence to a greater number of healthy lifestyle factors was associated with a significantly lower risk of mortality among individuals with osteoarthritis. Our findings hold important public health implications and provide empirical evidence that adhering to a healthy lifestyle could mitigate the burdens caused by osteoarthritis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.