ArticleIn vivo (Athens, Greece)
Quantification of
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Quantification of In Vitro Replicative Lifespan Elongation Activity of Hormones, Antioxidants, Plant Extract and Bacterial Exudate by Updated "Overlay Method".Medicines (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimWith an increasing number of comorbid diseases, the number of drug intake by elderly people and their chances to X-ray exposure inevitably increase. However, it is unclear how these treatments affect longevity. Primary human diploid fibroblasts with limited life span have been used as a model system for the study of cellular senescence. Since MATERIALS AND
methodsCells were treated for 14 days with or without (as control) various concentrations of test samples in culture medium supplemented with fetal bovine serum (FBS), without medium changes, but overlayed with fresh medium to minimize the cell detachment and nutritional deprivation. From the dose-response curve, the elongation index of the survival time (EI) was calculated by the ratio of maximum viable cell number at the optimal concentration of the test sample to that of the control at Day 14.
resultsIn general, six human fibroblasts prepared from dermal, oral and lung tissues required higher concentrations of FBS than cancer cells. Dermal fibroblasts were selected as the target cells, based on their higher hormetic responses. Quercetin, hydrocortisone, sodium ascorbate, vanillic acid and vanillin showed higher EI values than estradiol, curcumin, resveratrol, phellamurin, sodium butylate and X-ray irradiation, but did not reach the levels of plant extracts.
conclusionThe present method may be useful to quantitate the RLE activity of external and internal factors alone or in combination, in the presence of an appropriate positive control.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.