ReviewMethods in molecular biology (Clifton, N.J.)2025
Molecular Mechanisms of Innate Immune Sensing of Exogenous RNAs.
Review in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Duck plague virus US2 promotes p62-mediated autophagic degradation of RIG-I to suppress antiviral signaling.Poultry science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA sensing by the immune system is a critical mechanism through which cells detect and respond to viral infections and other pathogenic threats. This process involves specialized receptors known as pattern recognition receptors (PRRs), such as Toll-like receptors and RIG-I-like receptors, which recognize distinct RNA structures or motifs associated with pathogens. Upon detection, these receptors activate signaling pathways that lead to the production of type I interferons and other cytokines, orchestrating an antiviral response. Exogenously delivered therapeutic RNAs, including small interfering RNAs and messenger RNAs, can unintentionally trigger innate immune responses by being recognized as foreign by PRRs. This can lead to inflammation or unintended immune responses that could reduce the efficacy of the therapy, by triggering therapeutic mRNA degradation and inhibition of translation. This review describes various RNA-sensing receptors and strategies to mitigate the immunogenicity of exogenously delivered RNAs.
Indexed as
Identifiers
40877499What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.