Evidence map›Paper›PMID 40877713›Full record

ArticleProbiotics and antimicrobial proteins2026

Characterization of the Probiotic Properties and Cholesterol Metabolism Regulation Potential of Lactiplantibacillus plantarum QL-19.

Mingkai Liu, Yanlei Han, Shanshan Wang, Yiming Wang, Hui Xu

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mingkai LiuShandong Food Ferment Industry Research & Design Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250000, China.
Yanlei HanShandong Food Ferment Industry Research & Design Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250000, China.
Shanshan WangShandong Food Ferment Industry Research & Design Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250000, China.
Yiming WangAdvanced Agricultural Technology Institute Qingdao Agricultural University, Qingdao, 266109, China.
Hui XuShandong Food Ferment Industry Research & Design Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250000, China. xuhuilaoshi2022@163.com.

Funding

Key Research and Development Program of Shandong Province 2023CXGC10713National Natural Science Foundation of China 32372319Qilu University of Technology (Shandong Academy of Sciences) Science, Education and Industry Integration Pilot Project Major Innovation Category 2024ZDZX05
6 · The paper itself

Abstract

Lactic acid bacteria (LAB) play a crucial role in food fermentation and human health. This study introduces Lactiplantibacillus plantarum (L. plantarum) QL-19, a novel probiotic strain isolated from traditional Hunan pickles and characterized via whole-genome sequencing and in vitro functional assays. The 3,396,702 genome contains 3236 predicted coding sequences, including genes associated with stress tolerance, adhesion, and cholesterol metabolism (cbh, cfa, and hydroxymethylglutaryl-CoA synthase). Genomic analysis further revealed biosynthetic gene clusters encoding antimicrobial and antioxidant compounds, emphasizing its functional versatility. A comprehensive safety assessment confirmed that QL-19 is non-pathogenic and non-hemolytic, meeting probiotic safety standards. In HepG2 cell-based experiments, L. plantarum QL-19 reduced intracellular total cholesterol levels. RT-qPCR and Western blotting were employed to evaluate the expression of genes and proteins involved in cholesterol metabolism. The results demonstrated that QL-19 enhanced cholesterol metabolism by upregulating the expression of SREBP2, LDLR, and CYP7A1, while downregulating NPC1L1 and HMGCR. The results suggest that QL-19 facilitates cholesterol metabolism through multiple pathways. Taken together with its 75.4% in vitro cholesterol degradation rate, these findings highlight the potential of QL-19 as a cholesterol-lowering probiotic candidate for cardiovascular health applications.

Indexed as

CholesterolLactiplantibacillus plantarumProbioticsCholesterol 7-alpha-HydroxylaseHep G2 CellsHumansMembrane Transport ProteinsReceptors, LDLSterol Regulatory Element Binding Protein 2CholesterolCholesterol 7-alpha-HydroxylaseCYP7A1 protein, humanLDLR protein, humanMembrane Transport ProteinsNPC1L1 protein, humanReceptors, LDLSREBF2 protein, humanSterol Regulatory Element Binding Protein 2Cholesterol-loweringGenome-wide sequencingLactiplantibacillus plantarumProbioticsSafety

Identifiers

PMID40877713

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.