Evidence map›Paper›PMID 40877716›Full record

ReviewInternal and emergency medicine2025

Opioid-induced constipation in internal medicine: recognition and management pathways.

Piero Portincasa, Chiara Valentina Luglio, Silvia Sozzi, Claudia Conforti, Gianluca Bitonto, Michele Papavero, Gyorgy Baffy, Agostino Di Ciaula

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Piero PortincasaDivision of Internal Medicine 'A. Murri' and Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari 'Aldo Moro', Bari, Italy. piero.portincasa@uniba.it.ORCID 0000-0001-5359-1471
Chiara Valentina LuglioDivision of Internal Medicine 'A. Murri' and Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari 'Aldo Moro', Bari, Italy.
Silvia SozziDivision of Internal Medicine 'A. Murri' and Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari 'Aldo Moro', Bari, Italy.
Claudia ConfortiDivision of Internal Medicine 'A. Murri' and Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari 'Aldo Moro', Bari, Italy.
Gianluca BitontoDivision of Internal Medicine 'A. Murri' and Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari 'Aldo Moro', Bari, Italy.
Michele PapaveroDivision of Internal Medicine 'A. Murri' and Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari 'Aldo Moro', Bari, Italy.
Gyorgy BaffyDepartment of Medicine, VA Boston Healthcare System, Boston, MA, USA.
Agostino Di CiaulaDivision of Internal Medicine 'A. Murri' and Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari 'Aldo Moro', Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid-induced constipation (OIC) remains one of the most frequent and distressing gastrointestinal side effects encountered by patients on chronic opioid therapy. Despite the high prevalence, OIC is frequently underdiagnosed and inadequately managed, with critical effects on the quality of life of patients. Aim of this review is to promote the awareness about OIC in the context of internal medicine. We examined the statement EnhanCing Healthcare Outcomes in Opioid-Induced Constipation (ECHO OIC) by European experts to streamline the diagnosis and management of OIC in clinical practice. Such guidelines have been further discussed by an Italian expert consensus to provide national customization and a multidisciplinary approach. The key finding is the implementation of a multi-step clinical pathway for prevention, diagnosis, treatment, and long-term management of OIC, taking into account the improvement of quality of life of patients. In conclusion, we urge to expand awareness about OIC. The seven-step diagnostic-therapeutic pathway approach formulated by ECHO OIC is a pragmatic and scalable model to improve OIC management with emphasis on education, early intervention, monitoring, tailored pharmacologic strategies, and coordinated referral when necessary.

Indexed as

Analgesics, OpioidConstipationOpioid-Induced ConstipationCritical PathwaysHumansInternal MedicineQuality of LifeAnalgesics, OpioidBristol stool scaleGut transitLaxativesNaldemedinePolyethylene glycolRome IV criteria

Identifiers

PMID40877716
PMCPMC12476432

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.