Evidence map›Paper›PMID 40877782›Full record

ArticleBMC molecular and cell biology2025

Evolutionary and structural insights into DNMTs and TETs: decoding their functional heterogeneity and oncogenic roles in methylation regulation.

Siqi Yang, Xinyi Li, Lingling Bao, Jiafu Cui, Jing Liu, Shan Cong, Yongchun Zuo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC molecular and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siqi YangState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Xinyi LiState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Lingling BaoState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Jiafu CuiState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Jing LiuState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Shan CongState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China. 111987012@imu.edu.cn.
Yongchun ZuoState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China. yczuo@imu.edu.cn.

Funding

Central Guidance Fund for Local Science and Technology Development 2024ZY0168Group Project of Developing Inner Mongolia through Talents 2025TEL25National Natural Scientific Foundation of China 62171241Natural Science Foundation of Inner Mongolia Autonomous Region of China 2025QN03183
6 · The paper itself

Abstract

DNA methylation in mammals is dynamically regulated by DNMTs and TETs. Despite their critical roles, comparative structural analyses of these protein families have been relatively scarce. To address the above problems, this study first constructed a phylogenetic tree of DNMT and TET proteins to investigate their evolutionary relationships. Furthermore, the structural exploration revealed that both protein families possess conserved β-sheet structures and exhibit the characteristics of alternating β-sheets in their catalytic domains. Interestingly, DNMTs contain more α helices and fewer loops compared to TETs. Several notable structural changes were discovered, including unique flexibility of the CXXC domain and divergences in DNA binding mechanisms among DNMT1, TET1, and TET3. Additionally, the results showed that a distinctive loop present in DNMT2 may indicate its specialized functional role. This research provides fundamental evolutionary and structural insights into DNMT and TET proteins, emphasizing their significance in tissue-specific distribution and cancer signaling, thereby establishing a foundation for future investigations in the field of epigenetics.

Indexed as

DNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA MethylationEvolution, MolecularMixed Function OxygenasesProto-Oncogene ProteinsAmino Acid SequenceAnimalsDioxygenasesDNA (Cytosine-5-)-Methyltransferase 1HumansModels, MolecularPhylogenyDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesMixed Function OxygenasesProto-Oncogene ProteinsDNMTsPhylogenetic treeStructural comparative analysisTETsTissue-specific expression

Identifiers

PMID40877782
PMCPMC12392533

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.