Evidence map›Paper›PMID 40877849›Full record

ArticleVirology journal2025

Respiratory viral infections in hospitalized adults: a comparative clinico-laboratory study of RSV, HMPV, and influenza.

Santhosha Devadiga, Prasad Varamballi, Ujwal Shetty, Chiranjay Mukhopadhyay, Anup Jayaram

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Burden of Human Metapneumovirus in India: Epidemiological Trends and Clinical Impact.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026
    Review
  3. Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Santhosha Devadiga *Manipal Institute of Virology, Manipal Academy of Higher Education, Madhava Nagar, Manipal, 576104, Karnataka, India.
Prasad VaramballiManipal Institute of Virology, Manipal Academy of Higher Education, Madhava Nagar, Manipal, 576104, Karnataka, India.
Ujwal ShettyManipal Institute of Virology, Manipal Academy of Higher Education, Madhava Nagar, Manipal, 576104, Karnataka, India.
Chiranjay MukhopadhyayManipal Institute of Virology, Manipal Academy of Higher Education, Madhava Nagar, Manipal, 576104, Karnataka, India.
Anup JayaramManipal Institute of Virology, Manipal Academy of Higher Education, Madhava Nagar, Manipal, 576104, Karnataka, India. anup.jayaram@manipal.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory viral infections, including Human Metapneumovirus (HMPV), Influenza (Flu), and human Respiratory Syncytial Virus (hRSV), are major global health concerns. While their impact on vulnerable groups is known, their characteristics in healthy adults (18-65 years) are less clear. This study aimed to determine the incidence and clinical-laboratory features of RSV and HMPV in this population and compared them with those of Influenza A(H1N1) and influenza A(H3N2) for improved epidemiological and diagnostic understanding. METHODOLOGY: A retrospective analysis was conducted on data from an Acute Febrile Illness surveillance (2016-2018) in Manipal, India. The study included 96 HMPV, 68 hRSV, 75 Influenza A(H1N1), and 76 Influenza A(H3N2) positive hospitalized adults with fever (≥ 38 °C) and respiratory illness confirmed by RT‒PCR. Clinical and laboratory data collected within the first 8 days of illness were statistically analyzed.

resultsThe annual incidence rates of hRSV (0.33%-1.59%) and HMPV (0.14%-1.79%) varied. Coryza was common, but cough was most frequent in HMPV (97.9%). HMPV also resulted in increased rates of shortness of breath and chest pain. Leucopenia was most common in Influenza A(H1N1) patients, and thrombocytopenia was most common in hRSV patients. Significantly elevated leukocyte and platelet counts were observed in HMPV patients. Liver enzyme abnormalities are relatively common in hRSV and Influenza A(H1N1) patients. Symptom progression and laboratory trends revealed distinct patterns across the viruses.

conclusionDespite overlapping initial symptoms, HMPV, hRSV, and influenza resulted in different clinical and laboratory profiles in adults. HMPV was associated with more prominent lower respiratory symptoms and a stronger inflammatory response. These distinctions can aid in the clinical differentiation and management of these common respiratory viruses in adults, highlighting the importance of timely diagnosis for improved patient care and public health strategies.

Indexed as

Influenza, HumanParamyxoviridae InfectionsRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsAdolescentAdultAgedFemaleHospitalizationHumansIncidenceIndiaInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeMaleMetapneumovirusClinicalComparative studyHuman metapneumovirusHuman respiratory syncytial virusInfluenzaLaboratory

Identifiers

PMID40877849
PMCPMC12395677

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.