SynthesisStem cell research & therapy2025
Evaluation of stem/stromal cell transplantation safety and efficacy in children diagnosed with cerebral palsy: A systematic review and meta-analysis of randomized controlled trials.
Synthesis in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Stem cell-based therapies in pediatric disorders: translational advances, unresolved challenges, and future horizons.Stem cell research & therapy · 2026Review
- Regenerative medicine approaches for children with cerebral palsy: a systematic review of clinical safety and effectiveness.Translational pediatrics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral palsy is a neurological disorder that affects both postnatal and prenatal children. It results from brain damage in the cerebral motor cortex. The three types of CP are spastic, dyskinetic, and mixed forms. This study aims to evaluate the efficacy and safety of stem or stromal cell therapy in children diagnosed with cerebral palsy. A systematic search was conducted across four databases: PubMed, ISI Web of Science, Scopus, and Embase from inception to August 23, 2024, to identify studies evaluating the efficacy and safety of stem cell therapy for cerebral palsy. Data extraction was performed for all randomized controlled clinical studies. ROB2 (Risk of Bias Tool 2) was used to assess the risk of bias in the included studies. The main outcome measures were extracted from each study for meta-analysis, and a PRISMA flow diagram was used to illustrate the study selection process. Eventually, thirteen studies met the inclusion criteria. The Gross Motor Function Measure (GMFM) is crucial for assessing motor function changes and evaluating the impact of stem cell therapy. Subgroup analysis of GMFM scores were conducted based on assessment time points (3, 6, and 12 months post-treatment), route of administration, and type of stem cell used. The results demonstrate that stem cell therapy remarkably improved GMFM score in the treatment group. For safety analysis, adverse events such as irritability, fever, nausea, and vomiting were assessed, and risk ratios (RRs) were calculated to confirm the safety of stem cell therapy.
conclusionThe findings suggest that stem cell transplantation was safe and effective for treating cerebral palsy. However, further high-quality RCTs with standardized protocols are necessary to investigate the efficacy of alternative stem cell types for cerebral palsy.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.