Evidence map›Paper›PMID 40878115›Full record

ReviewThe world journal of men's health2026

N6-Methyladenosine RNA Methylation: A Key Regulator in Male Reproductive Disorders and Urological Cancers.

Xiaopeng Huang, Xiaoya Li, Xiucheng Lan, Meijing Wang, Jingyi Zhang, Liang Dong, Junjun Li, Xujun Yu, Renbin Yuan, Fang Yang

Abstract readReview
In one paragraph

Review in The world journal of men's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaopeng Huang *TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0000-0002-7560-8278
Xiaoya Li *School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0009-0005-3543-6589
Xiucheng LanSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0000-0001-9830-3525
Meijing WangSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0000-0002-8292-8616
Jingyi ZhangSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0000-0002-7977-0336
Liang DongSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0000-0002-6628-2106
Junjun LiReproductive Medicine Center, Chengdu Fifth People's Hospital, The Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0000-0002-2956-9079
Xujun YuSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0000-0002-5620-6783
Renbin YuanTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. yuanrenbin123@163.com.ORCID https://orcid.org/0000-0002-7760-9231
Fang YangSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. yangfang@cdutcm.edu.cn.ORCID https://orcid.org/0000-0002-3964-1791

Funding

National Natural Science Foundation of China 82205131Xinglin Scholar Research Premotion Project of Chengdu University of TCM MPRC2023057Xinglin Scholar Research Premotion Project of Chengdu University of TCM XJ2023002701
6 · The paper itself

Abstract

In the field of male health, disorders of the reproductive and urological systems present significant challenges. The global increase in male infertility, primarily attributed to environmental and lifestyle factors, along with the high incidence of urological cancers, not only places a significant socio-economic burden but also emphasizes the urgent need for in-depth research. Epigenetic modifications, especially N6-methyladenosine (m6A) methylation, are of great importance in these conditions. m6A, which is regulated by specific "writer", "eraser", and "reader" proteins, has an impact on various RNA-related processes. This review summarizes the regulatory functions of m6A in male reproductive health and urological cancers. In male reproduction, it explores how m6A affects somatic cell functions, steroidogenesis, and the blood-testis barrier. It also delves into its role in diabetic erectile dysfunction and benign prostatic hyperplasia. In urological cancers, the review examines m6A's influence on metabolic reprogramming, programmed cell death, and tumor immunity. Furthermore, this review discusses the potential of targeting m6A as a therapeutic approach for these conditions. By integrating recent research findings, it offers new perspectives on the role of m6A in male reproductive and urological disorders, laying a foundation for future research.

Indexed as

Endocrine disruptorsInfertility, maleRNA methylationUrologic neoplasms

Identifiers

PMID40878115
PMCPMC13302978

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.