ArticleJournal of clinical neurology (Seoul, Korea)2025
Association Between Small Vessel Disease and Migraine: A Study Based on Peak Width of Skeletonized Mean Diffusivity.
Article in Journal of clinical neurology (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Alterations in white matter integrity in patients with postherpetic neuralgia evidenced by peak width of skeletonized mean diffusivity analysis.The Korean journal of pain · 2026Article
- Real-world effectiveness and safety of CGRP monoclonal antibodies in elderly migraine patients: a Korean multicenter study.The journal of headache and pain · 2026Article
- Altered perivascular-aligned diffusivity in postherpetic neuralgia assessed by the DTI-ALPS index.Frontiers in neuroscience · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
background and purposeMigraine is a common neurological disorder associated with structural and functional brain changes, while small vessel disease (SVD) is the leading cause of white matter damage in older adults. Diffusion tensor imaging (DTI) is effective for assessing white matter, and the peak width of skeletonized mean diffusivity (PSMD) is a novel marker for such damage. No study has used PSMD to assess SVD in migraine patients. This study aimed to investigate the relationship between migraine and SVD using PSMD.
methodsSeventy-three migraine patients and 73 healthy controls underwent brain DTI to calculate PSMD. Clinical data on migraine characteristics were collected. We compared PSMD values between groups and analyzed correlations with clinical factors in patients with migraine.
resultsPatients with migraine had a significantly higher PSMD than healthy controls (2.08×10⁻⁴ mm²/s vs. 2.04×10⁻⁴ mm²/s,
conclusionsOur findings indicate a potential association between migraine and SVD, with PSMD serving as a useful MRI marker for assessing white matter damage in headache disorders.
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