SynthesisThe Indian journal of medical research2025
Expression profile of cancer stem cell markers SOX2, OCT4 & NANOG in salivary gland malignancies: A systematic review.
Synthesis in The Indian journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Rewiring Cellular Context as A Central Mechanism Governing Cancer Stem Cell Survival: Insights from ESC Comparisons.Stem cell reviews and reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & objectives Cancer stem cells influence aggressive biology, metastasis, recurrence, and treatment resistance in various malignancies. The transcription factors SRY-box transcription factor 2 (SOX2), Octamer-binding transcription factor 4 (OCT4), and Homeobox protein NANOG (NANOG) are prime controllers of the signalling circuit required for embryonic stem cell pluripotency. Salivary gland tumours exhibit diverse biological and clinical behaviours ranging from a benign, innocuous nature to highly aggressive tumours, with a great tendency for recurrence, and poor prognosis. Advances in therapeutic modalities have also been limited. This systematic review aims to uncover the differential expression and influence of SOX2, OCT4, and NANOG in salivary gland malignancies. This could help the stratification of high-risk patients and the identification of newer prognostic and predictive remedial targets. Methods PubMed, Scopus, Google Scholar, and Clinical key databases were searched for relevant articles, and studies that met the eligibility criteria were selected. Results Ten articles that fulfilled the eligibility criteria were included. All the studies supported the role of the studied markers as prognosticators and potential therapeutic targets. Interpretation & conclusion The aforementioned transcription factors might have contributed to aggressiveness and poor prognosis. Thus, it has been inferred that a combination of these factors may serve as a marker to determine the behaviour and therapeutic approaches for salivary gland malignancies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.