Evidence map›Paper›PMID 40878635›Full record

ReviewJournal of neurochemistry2025

Regulatory Dynamics of Nrf2 With Sirtuins in the Brain: Exploring Cellular Metabolism, Synaptic Plasticity, and Defense Mechanisms.

Efrain J Perez Lao, Eric Fagerli, Fernando Ferrier, Juan I Young, Miguel A Perez-Pinzon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Molecules (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Efrain J Perez LaoPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Eric FagerliPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Fernando FerrierPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Juan I YoungHussman Institute for Human Genetics, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Miguel A Perez-PinzonPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.ORCID https://orcid.org/0000-0001-6555-8935

Funding

MECHANISMS OF NEUROPROTECTION AGAINST CARDIAC ARRESTR01NS045676 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2004 to 2024
$5.1M
ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTIONRF1NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2022 to 2022
$1.7M
Mitochondria and Cerebral ischemia: intracellular signalingR01NS054147 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2006 to 2009
$1.3M
NIH HHS 2RF1NS034773-20NIH HHS R01NS054147NIH HHS R01NS45676NINDS NIH HHS R01 NS045676NINDS NIH HHS R01 NS054147NINDS NIH HHS RF1 NS034773
6 · The paper itself

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a pivotal role as a transcription factor at the heart of cellular defense mechanisms against oxidative stress, orchestrating a suite of cytoprotective genes. This review places particular emphasis on the interplay between Nrf2 and Sirtuins-NAD

Indexed as

BrainNeuronal PlasticityNF-E2-Related Factor 2SirtuinsAnimalsHumansOxidative StressNFE2L2 protein, humanNF-E2-Related Factor 2Sirtuinsbioenergeticsepigenetic reprogrammingmetabolic plasticitymitochondria and transcriptomic adaptationpreconditioning strategies

Identifiers

PMID40878635
PMCPMC12395324

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.