Evidence map›Paper›PMID 40878765›Full record

ArticleJournal of biomedical research2025

The mediating effect of blood pressure between healthy lifestyles and stroke: Results from the China Kadoorie Biobank study.

Zidong Wang, Jiaxi Zhou, Xikang Fan, Jian Su, Houyue Geng, Xun Wu, Yujie Hua, Hongfu Ren, Jun Lyu, Pei Pei and 5 more

Abstract read
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In one paragraph

Article in Journal of biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zidong WangSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Jiaxi ZhouSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Xikang FanDepartment of Noncommunicable Chronic Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China.
Jian SuSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Houyue GengSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Xun WuDepartment of Noncommunicable Chronic Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China.
Yujie HuaDepartment of Noncommunicable Chronic Disease Control and Prevention, Suzhou City Center for Disease Control and Prevention, Suzhou, Jiangsu 215004, China.
Hongfu RenDepartment of Noncommunicable Chronic Disease Control and Prevention, Wuzhong District of Suzhou City Center for Disease Control and Prevention, Suzhou, Jiangsu 215100, China.
Jun LyuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Pei PeiPublic Health and Epidemic Preparedness and Response Center, Peking University, Beijing 100191, China.
Canqing YuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Dianjianyi SunDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Yan LuDepartment of Noncommunicable Chronic Disease Control and Prevention, Suzhou City Center for Disease Control and Prevention, Suzhou, Jiangsu 215004, China.
Jinyi ZhouSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Ran TaoSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

Funding

Wellcome Trust
6 · The paper itself

Abstract

While a healthy lifestyle is known to reduce the risk of stroke, the extent to which blood pressure (BP) mediates this association remains unclear. The present study aimed to quantify the mediating role of BP in the association between combined lifestyle factors and stroke incidence. Using data from 51929 participants free of major cardiovascular diseases or cancer at baseline, we employed structural equation modeling to assess the mediating effects of systolic (SBP) and diastolic (DBP) blood pressure. During the follow-up, 2811 incident stroke cases were identified. A healthy lifestyle was significantly associated with a reduced risk of stroke, with SBP mediating 44.70% (

Indexed as

blood pressurelifestylemediation analysisstroke

Identifiers

PMID40878765
PMCPMC12799335

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.