ArticleFEBS letters2025
The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non-cell-autonomous HLS1-AMP1 signaling in a region-specific manner.
Article in FEBS letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidrug and toxin extrusion (MATE) transporters are widely conserved across all domains of life and play diverse roles in plant development. Here, we investigated the role of DETOXIFICATION 51 (DTX51), a MATE transporter in Arabidopsis. Overexpression of DTX51 led to pleiotropic phenotypes resembling those of hls1 hlh1 and amp1 lamp1 loss-of-function mutants, which have disruptions of key developmental regulators that act non-cell-autonomously. Genetic and gene expression analyses revealed that DTX51 and HLS1 act within the same genetic pathway, forming a negative feedback loop at the transcriptional level. Spatially restricted overexpression experiments showed that, in contrast to HLS1 and AMP1, DTX51 acts in a region-specific manner within the shoot apical meristem, suggesting that DTX51 fine-tunes development locally by modulating non-cell-autonomous signals. Impact statement This study reveals a role of the MATE transporter DTX51, whose transport substrate remains unknown, in Arabidopsis development, providing new insights into how this transporter fine-tunes non-cell-autonomous signals generated by the HLS1-AMP1 module.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.