Evidence map›Paper›PMID 40878906›Full record

ArticleACR open rheumatology2025

Characteristics Associated With Detectable High-Sensitivity Cardiac Troponin in Patients With Rheumatoid Arthritis at Low-Intermediate Cardiac Risk.

Ilana Usiskin, Mary Jeffway, Ying Qi, Nancy Shadick, Michael Weinblatt, Brittany Weber, Katherine Liao

Abstract read
In one paragraph

Article in ACR open rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ilana UsiskinBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Mary JeffwayBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Ying QiBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Nancy ShadickBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0003-3953-845X
Michael WeinblattBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Brittany WeberBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0002-0177-2091
Katherine LiaoBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0002-4797-3200

Funding

Lipids, Inflammation, and Cardiovascular Risk in Rheumatoid ArthritisR01HL127118 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIAO, KATHERINE PHOENIX · 2016 to 2020
$4.1M
Mentoring Patient-Oriented Research Leveraging Bioinformatics to Study CV Risk in Rheumatic DiseaseK24AR085342 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Katherine Phoenix Liao · 2025 to 2026
$319k
Gordon and Llura Gund FoundationHarold and DuVal Bowen FundNHLBI NIH HHS R01 HL127118NIAMS NIH HHS K24 AR085342NIAMS NIH HHS R01 HL127118
6 · The paper itself

Abstract

objectiveThe objective of this study was to identify factors associated with detectable high-sensitivity cardiac troponin T (hs-cTnT), a marker of subclinical myocardial injury associated with cardiac events in rheumatoid arthritis (RA), among patients with RA at low to intermediate atherosclerotic cardiovascular disease (ASCVD) risk.

methodsWe performed a cross-sectional cohort study among patients with RA, excluding those with pre-existing cardiovascular disease or high estimated 10-year ASCVD risk (>20%). In univariable analysis, we compared demographics, RA clinical factors, markers of inflammation, and routine lipids among patients with and without detectable hs-cTnT. Multivariable logistic regression models were constructed to determine whether clinical factors and clinically available biomarkers were associated with detectable hs-cTnT, independent of ASCVD risk.

resultsWe studied 294 patients with RA, of whom 86 (29%) had a detectable hs-cTnT level. Older age; male sex; hypertension; higher levels of high-sensitivity C-reactive protein, interleukin-6, and lipoprotein-associated phospholipase A

conclusionDetectable hs-cTnT was prevalent among a cohort of patients with RA with low to intermediate ASCVD risk. Patients who were male or aged >60 had the highest rates of detectable hs-cTnT, suggesting a role for additional screening in these individuals regardless of their ASCVD risk.

Identifiers

PMID40878906
PMCPMC12317461

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.