Evidence map›Paper›PMID 40878960›Full record

ArticleAnimal models and experimental medicine2025

A comparative study of human ovarian tissue xenotransplantation in two different strains of rats.

Mohammad Ayoubipour, Hussein Eimani, Rouhollah Fathi, Mohammad Kazemi Ashtiani, Ashraf Moinie, Parviz Golmohammadi Gerdkohi

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad AyoubipourDepartment of Developmental Biology, Faculty of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.ORCID 0009-0001-7187-6785
Hussein EimaniDepartment of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
Rouhollah FathiDepartment of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
Mohammad Kazemi AshtianiDepartment of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Ashraf MoinieDepartment of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
Parviz Golmohammadi GerdkohiDepartment of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.

Funding

Royan Lotus Charity Foundation 1400/2450
6 · The paper itself

Abstract

This study aims to conduct a comparative study of two strains of laboratory rats, hooded and Wistar, to select a suitable alternative to nude rats for ovarian tissue xenotransplantation. The study investigated the effects of ovarian tissue transplantation using three experimental groups: (1) the control group receiving vitrified-warmed human ovarian tissue, (2) the OTW (ovarian tissue transplantation in Wistar) group with human ovarian tissues in Wistar rats, and (3) the OTH (ovarian tissue transplantation in hooded) group with ovarian tissues transplanted into hooded rats. A total of 12 rats (6 each from the two transplantation groups) were used, with tissue samples implanted in the dorsal neck muscles. Outcomes were evaluated using histological analyses, including hematoxylin and eosin and Masson's trichrome staining, as well as immunohistochemical assessments of CD31 for angiogenesis, fibrosis, and necrosis. The OTH group exhibited more blood vessel numbers and the Vegf gene expression than both the OTW and control groups, with significantly lower levels of fibrosis and necrosis compared to the OTW and control groups. The study indicates that hooded rats could serve as a valuable alternative for specific research when nude mice are not available. Their immune systems are more compatible with human ovarian tissue transplants than Wistar rats, and they exhibit calmer behaviors, making them better suited for laboratory work.

Indexed as

HeterograftsOvaryTransplantation, HeterologousAnimalsFemaleHumansRatsRats, NudeRats, WistarSpecies SpecificityVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Aangiogenesishooded rathuman ovarian tissueWistar ratxenotransplantation

Identifiers

PMID40878960
PMCPMC12464865

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.