ArticleJournal of the American Heart Association2025
Future of Families: Cardiovascular Health Among Young Adults Cohort Study: Rationale, Key Questions, Study Design, and Participant Characteristics.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Associations of county-level school expenditure around time of birth and cardiovascular health in young adulthood.American journal of preventive cardiology · 2026Article
- Association Between Cardiovascular-Kidney-Metabolic Health and Early Arterial Injury in Young Adults in the United States: The Future of Families-Cardiovascular Health Among Young Adults Study.Circulation. Population health and outcomes · 2026Article
- Cardiovascular health among young adults: Do childhood neighborhoods matter?SSM - population health · 2026Article
- Adverse Pregnancy Outcomes and Cardiovascular Health Among Offspring in Early Adulthood.JAMA network open · 2026Article
- Era to Action: 40 Years of Health Disparity Research in Cardiovascular Disease and the Path to Equity.Journal of the American Heart Association · 2026Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
backgroundChildhood social determinants of adult cardiovascular health and potential mechanisms that link them are poorly understood. The FF-CHAYA (Future of Families-Cardiovascular Health Among Young Adults) study is designed to address these knowledge gaps.
methodsThe FF-CHAYA sample is a subcohort of the Future of Families and Child Wellbeing Study, which enrolled 4897 mother-baby dyads at delivery beginning in 1998 to 2000 and collected extensive data on neighborhood, family, school, and behavioral exposures at birth and offspring ages 1, 3, 5, 9, 15, and 22 years. From 2021 to 2023, we performed an in-person examination on 1421 offspring, including obtaining questionnaire responses addressing health status and health behaviors, and performance of anthropometry, blood pressure measurement, phlebotomy, and carotid ultrasonography using standardized protocols. An additional 620 offspring answered questionnaires electronically. Cardiovascular health status was quantified using the Life's Essential 8 score (0-100; higher is better cardiovascular health). Measurement of carotid intima-media thickness, grayscale lucency, and carotid distensibility was performed.
resultsAmong 1975 nonpregnant participants, mean age was 23.2±0.8 years, 55% identified as female, 19.5% White, 49.1% Black, 26.7% Hispanic, and 4.7% as Asian or multiple race/ethnicity. Mean body mass index was 29.0±8.2 kg/m
conclusionsThis article describes the rationale, study design and methods, and characteristics of the FF-CHAYA cohort, a novel longitudinal study designed to examine associations of childhood social determinants with young adult cardiovascular health and early arterial injury, as well as potential epigenetic mechanisms that may mediate these associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.